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GlossaryMelanocyte Stem Cells (McSCs)

specialized cells that develop into pigment-producing melanocytes

Melanocyte stem cells are specialized cells found in the hair follicles and skin that have the ability to develop into melanocytes, which are the cells responsible for producing melanin, the pigment that gives color to hair, skin, and eyes. These stem cells play a crucial role in the regeneration of melanocytes, helping to maintain pigmentation and potentially offering insights into treatments for conditions like vitiligo and age-related graying of hair.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations, June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

59 citations, April 2016 in “Cell Reports”

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

research Wnt/β-Catenin Signaling Pathway Activates Melanocyte Stem Cells In Vitro and In Vivo

45 citations, April 2016 in “Journal of Dermatological Science”

The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.

research CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties

41 citations, April 2019 in “PLOS genetics”

CD34+ and CD34- melanocyte stem cells have different regenerative abilities.

Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

research Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

41 citations, December 2018 in “Experimental Dermatology”

Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.

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community Microneedling and aloe vera to recruit stem cells.

in Chat 11 upvotes 1 year ago

Microneedling combined with aloe vera may stimulate dormant stem cells in hair loss areas. Minoxidil is also suggested for better results.