Aqueous Dispersion of Unmodified Fullerene C60: Stimulation of Hair Growth and Study of a New Molecular Target for Interaction

    N.N. Shershakova, Elena Baraboshkina, Д. А. Хоченков, Evgeny A. Turetskiy, Alexandra Nikonova, Oleg Kamyshnikov, Darya K. Bolyakina, Veronika A. Parshina, Daria Shabanova, Evelina Makarova, Sergey Andreev, D.А. Кudlay, Musa Khaitov
    TLDR Unmodified fullerene C60 promotes hair growth and may help treat hair loss.
    The study examines the effects of an aqueous dispersion of unmodified fullerene C60 (ADF) on hair growth in nu/nu mice, finding that ADF significantly stimulates hair growth by increasing the number of hair follicles in the anagen phase. This effect persists even after stopping ADF administration. ADF influences the Wnt-signaling pathway, increases Wnt10b and angiogenetic factors, and reduces tumor necrosis factor-alpha levels. The proposed mechanism involves ADF attracting macrophages to the hair follicle microenvironment and promoting their polarization to the M2 phenotype. Additionally, ADF may interact with the adenosine A2A receptor, potentially decreasing tumor necrosis factor-alpha production. These findings suggest ADF could be a promising candidate for developing new treatments for alopecia related to immune disorders.
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