Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress During Hair Cycling

    July 2015 in “ PloS one ”
    Jianzhi Zhao, Hanjun Li, Rujiang Zhou, Gang Ma, Joseph D. Dekker, Haley O. Tucker, Zhengju Yao, Xizhi Guo
    TLDR Foxp1 helps control hair stem cell growth and response to stress during hair growth cycles.
    The study concluded that the transcription factor Foxp1 was crucial for regulating hair follicle stem cell (HFSC) proliferation in response to oxidative stress during hair cycling. Foxp1 dynamically relocated between the nucleus and cytoplasm in response to oxidative stress, with phosphorylation at S468 influencing this process. Foxp1 deficiency led to increased HFSC proliferation, reduced oxidative stress, and impaired hair growth. Foxp1 interacted with Thioredoxin-1 (Trx1) to modulate oxidative stress, ensuring proper hair cycling and growth. These findings suggested that targeting Foxp1 could be a potential therapeutic strategy for hair loss conditions related to oxidative stress.
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