In Vivo Hair Growth-Stimulating Effect of Medicinal Plant Extract on BALB/c Nude Mice

January 2015 in “ Pharmaceutical Biology ”

Shahnaz Begum, Lijuan Gu, Mi-Ra Lee, Zheng Li, Jingjie Li, Md. Jamil Hossain, Yunbo Wang, Chang-Keun Sung

Chrysanthemum zawadskii var. latilobum Polygonum multiflorum Minoxidil hair growth nude mice baldness hair follicles keratinocyte proliferation alopecia CZ extract PM extract Rogaine hair loss bald mice hair roots skin cell growth

Studysummary In a study on nude mice, topical application of Chrysanthemum zawadskii extracts stimulated hair growth and increased hair follicle numbers, suggesting potential for alopecia therapy. Our plain-language summary of this paper — not a Tressless recommendation.

The study from 2015 examined the effects of Chrysanthemum zawadskii var. latilobum (CZ) and Polygonum multiflorum (PM) extracts on hair growth in nude mice, which are genetically prone to baldness. The mice were treated with these extracts, a vehicle solution, and Minoxidil for 40 days. Results indicated that the CZ extract was more effective than Minoxidil, as evidenced by a higher hair score (2.5±0.29) and an increased number of hair follicles (58.66±3.72) in the CZ-treated group. Immunohistochemical analysis showed increased keratinocyte proliferation in the hair follicles of both CZ and Minoxidil groups. The study concluded that CZ extract could be a promising treatment for alopecia, as it promotes hair follicle restoration by inducing keratinocyte proliferation. The exact number of mice used in the study was not mentioned.

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