54 citations
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April 2019 in “Journal of cellular physiology” miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.
45 citations
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April 2016 in “Journal of Dermatological Science” The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.
45 citations
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August 2009 in “American Journal Of Pathology” The study investigated the role of the bone morphogenetic protein (BMP) antagonist noggin in skin tumorigenesis using transgenic mice, which developed hair follicle-derived tumors resembling human trichofolliculoma. Noggin overexpression led to abnormal activation of the Wnt and Shh signaling pathways, crucial for tumor initiation and progression. Pharmacological inhibition of these pathways resulted in stage-dependent tumor suppression. BMP signaling was shown to suppress tumor formation by stimulating the expression of Wnt inhibitory factor-1, indicating a tumor-suppressive role in skin epithelium. The findings suggested that BMP antagonists like noggin could compromise BMP's tumor suppressor function, affecting tumor development in the skin and potentially other organs.
25 citations
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August 2017 in “Animal Biotechnology” Researchers found that certain RNA molecules might play a role in the growth of Cashmere goat hair.
18 citations
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April 2019 in “Archives of Dermatological Research” Lactoferrin helps mice grow hair by increasing cell growth and hair follicle development.