M2 Macrophages Promote Wound-Induced Hair Neogenesis

    May 2018 in “ Journal of Dermatological Science ”
    Akira Kasuya, Taisuke Ito, Y. Tokura
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    Studysummary This study suggests that M2 macrophages play a key role in promoting wound-induced hair neogenesis in mice by producing growth factors like Igf1 and Fgf2.
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    The study from August 31, 2018, established a mouse model of wound-induced hair neogenesis (WIHN), a phenomenon where new hair regeneration occurs in scars. The researchers hypothesized that M2 macrophages, a type of immune cell, were crucially involved in WIHN. They found that these macrophages infiltrated the tissue 2 weeks after wounding and produced various growth factors. Administration of two of these growth factors, Igf1 or Fgf2, promoted WIHN. When macrophages were removed in genetically engineered mice, WIHN decreased. The study concluded that M2 macrophages could promote WIHN through producing a panel of growth factors.
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