Augmentation of HGF Signaling: Potential for Enhancing Hair Follicle Neogenesis and Development in Bioengineered Skin
April 2016
in “
Journal of Investigative Dermatology
”
HGF Hepatocyte Growth Factor hair follicle neogenesis bioengineered skin dermal papilla cells alkaline phosphatase RNA-Sequencing trichogenic cells WNT signaling HGF mRNA recombinant HGF HGF mimetic mitogen-activated protein kinases keratinocyte proliferation keratinocyte stratification hair follicle formation engineered skin dermal cells ALP gene sequencing hair-producing cells WNT pathway HGF gene expression synthetic HGF HGF-like compound MAPK skin cell growth skin cell layering
Studysummary This study suggests that hepatocyte growth factor (HGF) may play a role in hair follicle neogenesis and that an HGF mimetic could enhance skin substitute development.
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