Alopecia as a Systemic Disease

July 2019 in “ Clinics in Dermatology ”

Sonali Nanda, Valeria De Bedout, Mariya Miteva

Studysummary This review discusses various systemic diseases associated with secondary alopecia and reports no new clinical findings; it emphasizes the importance of addressing underlying conditions and using diagnostic tools like trichoscopy and histopathology.

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Research cited in this study

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research Increased Risk of Severe Course of Pemphigus in Patients with Pemphigus-Associated Alopecia: A Prospective Observational Study

2 citations , September 2018 in “Clinical and Experimental Dermatology”

This study found that pemphigus-associated alopecia indicates severe and treatment-resistant pemphigus, with higher disease activity and antibody levels compared to patients without alopecia.

research Distinctive Lupus Panniculitis of Scalp with Linear Alopecia Along Blaschko's Lines: A Review of the Literature

19 citations , August 2018 in “International Journal of Dermatology”

In this study, lupus panniculitis of the scalp was associated with a high incidence of recurrence and progression to systemic lupus erythematosus, despite various treatments showing complete response within weeks.

research Postoperative Alopecia Following Oral Surgery

3 citations , July 2018 in “Journal of Oral and Maxillofacial Surgery”

This report describes two cases of postoperative alopecia following oral surgery, highlighting potential risk factors such as head positioning and prolonged operative time, and suggests prevention strategies.

research Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus

46 citations , June 2018 in “American Journal of Clinical Dermatology”

This review summarizes the clinical, trichoscopic, and histopathological features of alopecia types associated with cutaneous and systemic lupus erythematosus and explores their links to disease activity, but it reports no new clinical results.

research Symptomatic Hypercalcemia and Scarring Alopecia as Presenting Features of Sarcoidosis

6 citations , March 2018 in “Proceedings - Baylor University. Medical Center”

This case report describes a patient with sarcoidosis who experienced severe symptomatic hypercalcemia, scarring alopecia, and acute-on-chronic kidney failure.

research Horizontal and Vertical Sections of Scalp Biopsy Specimens from Dermatomyositis Patients with Scalp Involvement

16 citations , February 2018 in “Journal of The American Academy of Dermatology”

This study found that scalp involvement in dermatomyositis consistently shows a nonscarring pattern with chronic telogen effluvium, featuring telangiectasia and mucin deposition as universal histologic markers.

research A Novel PLEC Nonsense Homozygous Mutation (c.7159G > T; p.Glu2387*) Causes Epidermolysis Bullosa Simplex with Muscular Dystrophy and Diffuse Alopecia: A Case Report

18 citations , January 2018 in “BMC dermatology”

This paper describes a case of epidermolysis bullosa simplex with muscular dystrophy associated with a novel PLEC mutation and diffuse alopecia, highlighting a potential genetic link that remains uncertain.

research Nonspecific Diffuse Alopecia as a Single Manifestation of Syphilis Infection: Clinical and Trichoscopic Features

7 citations , January 2018 in “International Journal of Dermatology”

Syphilis can cause hair loss without other symptoms and should be considered when diagnosing unexplained hair loss.

research The Significance of Scalp Involvement in Pemphigus: A Literature Review

13 citations , January 2018 in “BioMed Research International”

This review summarizes recent findings on scalp involvement in pemphigus vulgaris and pemphigus foliaceus, highlighting diagnostic methods and their underlying histopathological, immunopathological, and clinical features, but reports no new clinical results.

research Scalp Itch: A Systematic Review

28 citations , November 2017 in “Skin appendage disorders”

This paper proposes a systematic approach to evaluating scalp itch using the SCALLP acronym and highlights the importance of classifying cases based on the presence of dermatological lesions and hair loss, but it reports no new clinical findings.

research Syphilitic Alopecia: Uncommon Trichoscopic Findings

32 citations , July 2017 in “Dermatology practical & conceptual”

This study is the first to describe a mixed pattern of essential syphilitic alopecia using trichoscopy, identifying features like tapered bended hairs and perifollicular hyperkeratosis in a patient without secondary syphilis symptoms.

research Alopecia Developed in a Transitional Case from Pemphigus Foliaceus to Pemphigus Vulgaris

7 citations , July 2017 in “The Journal of Dermatology”

This letter to the editor notes a case where alopecia developed as pemphigus foliaceus transitioned to pemphigus vulgaris; it provides no new experimental findings.

research Miniaturization of Sebaceous Glands: A Novel Histopathological Finding in Pemphigus Vulgaris and Pemphigus Foliaceus of the Scalp

9 citations , June 2017 in “Journal of Cutaneous Pathology”

This study found that follicular acantholysis is a common histopathological feature in pemphigus, with differences in depth between pemphigus vulgaris and pemphigus foliaceus lesions that may aid in diagnosis.

research TNF-Inhibitor Associated Psoriatic Alopecia: Diagnostic Utility of Sebaceous Lobule Atrophy

20 citations , March 2017 in “Journal of cutaneous pathology”

This study describes tumor necrosis factor inhibitor-associated psoriatic alopecia, highlighting the distinctive histologic feature of sebaceous lobule atrophy, which is potentially reversible and helps differentiate it from idiopathic psoriatic alopecia.

research Sarcoidosis Presenting as Frontal Fibrosing Alopecia: A Master Mimicker or a Coincidental Finding?

3 citations , February 2017 in “The American journal of dermatopathology/American journal of dermatopathology”

This case report details a 73-year-old woman with systemic sarcoidosis, whose scalp biopsy revealed features consistent with both sarcoidosis and frontal fibrosing alopecia, emphasizing the necessity of biopsy in complex alopecia diagnoses.

research Tumor Necrosis Factor-Induced Alopecia: Alternative Pathology and Therapy

7 citations , January 2017 in “Dermatology Online Journal”

In this case report, the researchers described two women with Crohn disease who developed alopecia related to TNF inhibitor therapy, noting various histopathological features of drug-induced alopecia and treating it effectively with different therapeutic approaches.

research Syphilitic Alopecia: Case Reports and Trichoscopic Findings

29 citations , January 2017 in “Skin appendage disorders”

This case study highlights the importance of considering syphilis in the differential diagnosis for hair loss, as patients with the infection may present with non-typical alopecia patterns.

research The Ancient Remedies of Alopecia

2 citations , December 2016 in “JAMA dermatology”

This abstract does not present research findings but instead provides information about the JAMA Dermatology journal and its affiliations. No study results or conclusions are included.

research Leprosy on the Scalp: A Case Report

5 citations , October 2016 in “Anais Brasileiros de Dermatologia”

This report describes a rare case of leprosy involving the scalp, a location not typically conducive to Mycobacterium leprae infection, and adds to existing literature without presenting new experimental findings.

research CD8-Positive Mycosis Fungoides Clinically Masquerading as Alopecia Areata

8 citations , August 2016 in “Journal of Cutaneous Pathology”

This case report highlights a rare instance of CD8-positive hypopigmented mycosis fungoides causing alopecia areata-like changes, emphasizing the necessity of scalp biopsy in such presentations.

research Desmoplastic Melanoma Presenting as Primary Alopecia Neoplastica: A Report of Two Cases

8 citations , June 2016 in “Journal of Cutaneous Pathology”

This report describes two rare cases of desmoplastic melanoma presenting as alopecia neoplastica, highlighting a potential diagnostic pitfall for clinicians examining patients with scar-like alopecia.

research Special Stains and Immunohistochemical Stains in Hair Pathology

11 citations , April 2016 in “The American Journal of Dermatopathology”

This review discusses the current knowledge on using special and immunohistochemical stains for diagnosing hair disorders, concluding that no stains are recommended for routine use in hair pathology.

research Proposing a Simpler Classification of Telogen Effluvium

21 citations , January 2016 in “Skin appendage disorders”

This review proposes a new classification for telogen effluvium, identifying three pathogenetic types with a common feature of profuse hair shedding, but reports no new clinical results.

research Psoriatic Alopecia

41 citations , July 2015 in “Clinical and Experimental Dermatology”

This review explores the connection between psoriasis and hair loss, noting that both the disease and its treatments can contribute to alopecia, and reports no new clinical results.

research Alopecia as the Presenting Symptom of Syphilis

3 citations , January 2015 in “Dermatology Online Journal”

This case report highlights a patient whose essential syphilitic alopecia was the only symptom of syphilis, which improved after benzathine penicillin treatment, emphasizing alopecia as a potential sign of syphilis.

research Hair and Scalp Manifestations in Secondary Syphilis: Epidemiology, Clinical Features and Trichoscopy

45 citations , January 2015 in “Dermatology”

In this study, 41.6% of patients with secondary syphilis exhibited syphilitic alopecia, with the 'moth-eaten' pattern most commonly observed through trichoscopy.

Alopecia Neoplastica Due to Gastric Adenocarcinoma Metastasis to the Scalp, Presenting as Alopecia: A Case Report and Literature Review

research Alopecia Neoplastica Due to Gastric Adenocarcinoma Metastasis to the Scalp, Presenting as Alopecia: A Case Report and Literature Review

26 citations , January 2014 in “Annals of Dermatology”

This report describes a 33-year-old woman who developed alopecia neoplastica due to gastric adenocarcinoma, highlighting the role of tumor invasion in hair follicle atrophy.

research Alopecia Universalis Associated with Cutaneous T Cell Lymphoma

15 citations , January 2014 in “Dermatology”

This case report describes alopecia universalis-like hair loss occurring in two patients with cutaneous T cell lymphoma, providing clinical, dermoscopic, and pathologic features to help differentiate it from alopecia areata universalis.

research Non-Scarring Patchy Alopecia in Patients with Systemic Lupus Erythematosus Differs from That of Alopecia Areata

30 citations , October 2013 in “Lupus”

This study identified distinct clinical and dermatoscopic features to differentiate non-scarring patchy alopecia in SLE from alopecia areata, emphasizing the value of serological tests in diagnosis.

research Alopecia as a Rare but Distinct Manifestation of Pemphigus Vulgaris

23 citations , November 2011 in “Journal of the European Academy of Dermatology and Venereology”

This study observed that in pemphigus vulgaris patients, hair loss and alopecic patches may result from anti-desmoglein autoantibody-mediated acantholysis and inflammatory changes, leading to non-scarring alopecia with potential for regrowth after treatment.

research Hair Loss in Autoimmune Cutaneous Bullous Disorders

12 citations , May 2011 in “Dermatologic Clinics”

This review discusses the association between scarring alopecia and inflammatory processes in common acquired bullous disorders of the scalp, and reports no new clinical findings.

research Trichoscopy as a Clue to the Diagnosis of Scalp Sarcoidosis

33 citations , February 2011 in “International Journal of Dermatology”

This study observed that orange spots and dystrophic hairs on trichoscopy may aid in diagnosing scalp sarcoidosis.

research The Spectrum of Hair Loss in Patients with Mycosis Fungoides and Sézary Syndrome

39 citations , October 2010 in “Journal of The American Academy of Dermatology”

This study reported that alopecia occurred in 2.5% of patients with mycosis fungoides or Sézary syndrome, with some cases resembling alopecia areata and others associated with specific skin lesions.

research Alopecia in Epidermolysis Bullosa

21 citations , November 2009 in “Dermatologic Clinics”

This review discusses hair abnormalities in various epidermolysis bullosa subtypes and reports no new clinical findings.

research Woman With Hyperpigmented Plaque And Alopecia

2 citations , June 2009 in “Journal of the American Academy of Dermatology”

This case report describes a healthy 27-year-old woman with progressive alopecia and hyperpigmentation on her forehead and frontal scalp, with limited response to triamcinolone acetonide treatment.

Cross-Sectional Study of Hair Loss Patterns in 122 Korean Systemic Lupus Erythematosus Patients: A Frequent Finding of Non-Scarring Patch Alopecia

research Cross-Sectional Study of Hair Loss Patterns in 122 Korean Systemic Lupus Erythematosus Patients: A Frequent Finding of Non-Scarring Patch Alopecia

34 citations , June 2007 in “The Journal of Dermatology”

This study observed that non-scarring diffuse hair loss was common in systemic lupus erythematosus patients, but did not find a significant relationship with the SLE Disease Activity Index.

research Hair and Nail Involvement in Lupus Erythematosus

18 citations , March 2004 in “Clinics in Dermatology”

This review discusses recent advances in understanding the cellular, molecular, and genetic factors contributing to lupus erythematosus and reports no new experimental findings.

research Cicatricial Pemphigoid Rarely Involves the Scalp

15 citations , November 1998 in “Australasian Journal of Dermatology”

This review presents a case of cicatricial pemphigoid with scarring alopecia and notes its rarity but significant cosmetic distress among cicatricial pemphigoid patients in Oxford.