Cross-Sectional Study of Hair Loss Patterns in 122 Korean Systemic Lupus Erythematosus Patients: A Frequent Finding of Non-Scarring Patch Alopecia

June 2007 in “ The Journal of Dermatology ”

Sook Jung Yun, Jae‐Wook Lee, Hyun‐Jung Yoon, Shin Seok Lee, Seo‐Young Kim, Jee-Bum Lee, Seung−Chul Lee, Young-Ho Won, Seong‐Jin Kim

systemic lupus erythematosus non-scarring diffuse hair loss non-scarring patch alopecia alopecia areata pseudopelade histopathological differentiation SLE AA

TLDR Most Korean systemic lupus erythematosus patients experienced hair loss, often as non-scarring diffuse hair loss, with non-scarring patch alopecia also common.

In a study of 122 Korean systemic lupus erythematosus (SLE) patients, 85.2% (104 patients) experienced hair loss, with non-scarring diffuse hair loss being the most common pattern post-diagnosis (65.1%, 56/86 patients). Non-scarring patch alopecia was also notable, with an overall prevalence of 14.8% (18/122 patients). This type of alopecia was observed both before and after SLE diagnosis, and it presented clinical challenges in differentiation from alopecia areata (AA) or pseudopelade. The study did not find a significant correlation between hair loss patterns and SLE disease activity. The findings highlight the importance of recognizing non-scarring patch alopecia in SLE patients and suggest the need for histopathological differentiation from AA and other alopecias.

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