Non-Scarring Alopecia in Systemic Lupus Erythematosus Patients at the Lagos State University Teaching Hospital: A Cross-Sectional Study of Prevalence, Pattern, Trichoscopy Features and Histopathological Analysis

    January 2024 in “ Pan African Medical Journal ”
    Anaba Ehiaghe Lonia, Olaosebikan B. Hakeem, Cole-Adeife Olufolakemi, Olayemi Olubunmi Dawodu, Olufemi Adelowo
    Image of study
    TLDR Non-scarring hair loss is common in lupus patients and can be diagnosed with specific hair and tissue tests.
    The study at Lagos State University Teaching Hospital examined non-scarring alopecia in 75 systemic lupus erythematosus (SLE) patients, finding a 48% prevalence of non-scarring alopecia, with patchy hair loss being the most common pattern. Trichoscopy revealed hair shaft thinning, hypopigmentation, and scalp pigmentary changes, while histopathology showed reduced sebaceous glands and inflammatory changes even in normal-appearing scalp areas. The study concluded that non-scarring alopecia is prevalent in SLE patients and that trichoscopic and histopathologic differences exist between those with and without hair loss, indicating scalp involvement in the inflammatory process of SLE.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

      in Chat  15 upvotes 8 months ago
      A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

      community Topical Minoxidil is a pain in the ass for diffuse thinners

      in Minoxidil  95 upvotes 1 year ago
      Topical minoxidil being a difficult product to apply, with users considering finasteride, RU58841, and oral minoxidil as alternative treatments for diffuse thinning hair. Other advice includes shaving the head in the first 3 months of using minoxidil and finding ways to apply it without saturating the hair.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community How is there still no consensus on Topical Dutasteride in 2024?

      in Finasteride/Dutasteride  147 upvotes 7 months ago
      The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

    Related Research

    5 / 5 results