Nonscarring Alopecia in Systemic Lupus Erythematosus: A Cross-Sectional Study with Trichoscopic, Histopathologic, and Immunopathologic Analyses

    May 2019 in “ Journal of the American Academy of Dermatology ”
    Kumutnart Chanprapaph, Siriorn Udompanich, Yingluck Visessiri, Pintip Ngamjanyaporn, Poonkiat Suchonwanit
    TLDR Hair loss in lupus patients indicates higher disease activity.
    The study examined nonscarring alopecia in systemic lupus erythematosus (SLE) by analyzing 32 patients with alopecia and 10 without. It identified various alopecia patterns and found that nonscarring alopecia was associated with higher SLE disease activity, suggesting it could be an indicator of active SLE. Trichoscopic and histopathologic analyses revealed lupus-specific changes, such as arborizing vessels and interface changes at the dermoepidermal junction. The study concluded that nonscarring alopecia in SLE might share a distinct pathomechanism and highlighted the need for further research with larger cohorts to confirm these findings. Limitations included its small, single-center design and focus on Southeast Asian participants.
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