October 2024 in “Frontiers in Nutrition” This study found that patients with alopecia, particularly alopecia areata and female pattern hair loss, often have vitamin D deficiency, suggesting that screening for vitamin D could benefit these patients.
November 2023 in “International Journal of Dermatology” In this study, CCCA patients were found to have higher odds of metabolic, autoimmune, atopic, and psychiatric comorbidities compared to matched controls.
5 citations
,
November 2023 in “Journal of Investigative Dermatology” People with primary cicatricial alopecia have a higher risk of heart disease and stroke.
November 2023 in “Indian Journal of Dermatology” This study from North-East India analyzed 21 cases of frontal fibrosing alopecia, noting a high prevalence in post-menopausal women and distinct histological features such as perifollicular lymphocytic infiltrate and hydropic degeneration.
7 citations
,
October 2023 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” This article emphasizes the importance of educating dermatologists to reduce diagnostic delays in FD and highlights the need to screen for comorbid hidradenitis suppurativa and obtain bacterial cultures for effective treatment planning.
1 citations
,
September 2023 in “International Journal of Dermatology” In this study conducted at a tertiary dermatological clinic, researchers identified and described the clinical, dermoscopic, and histopathological features of preclinical folliculitis keloidalis, including novel dermoscopic findings such as perifollicular scale, which was associated with fibrosis.
1 citations
,
September 2023 in “Acta dermato-venereologica” In this study, researchers found that most patients with frontal fibrosing alopecia lacked the protective rs1800440 polymorphism in the CYP1B1 gene, suggesting its potential role in the development of this condition, while a significant number carried the rs9258883 polymorphism in HLA-B*07:02.
August 2023 in “JAAD international” This study, conducted at Montefiore Medical Center, reports that central centrifugal cicatricial alopecia predominantly affects middle-aged Black or African American women, often presenting without symptoms, which may delay diagnosis and treatment. The study underscores the need for a specific ICD-10 code for better epidemiological studies.
2 citations
,
July 2023 in “International Journal of Dermatology” This meta-analysis found an increased prevalence of hypothyroidism in patients with lichen planopilaris compared to controls, though the exact relationship between the two conditions remains unclear.
In this retrospective study, researchers at a Spanish hospital found that the severity of frontal fibrosing alopecia, primarily affecting postmenopausal women, was correlated with the duration of the disease, though inflammatory signs were not linked with its progression.
11 citations
,
May 2023 in “Journal of Cutaneous Medicine and Surgery” This study found that combining plasma rich in growth factors with conventional treatment significantly improved hair regrowth and reduced symptoms in patients with frontal fibrosing alopecia compared to conventional treatment alone.
May 2023 in “Archives of dermatological research” This study found that clinical characteristics, concurrent medical conditions, and hair care practices may affect treatment outcomes in patients with central centrifugal cicatricial alopecia.
April 2023 in “JAAD international” This study observed that among a Moroccan population with frontal fibrosing alopecia, common comorbidities included lichen planus pigmentosus (36.8%), rosacea (28.9%), thyroid disorders (23.7%), and dyslipidemia (21.1%), highlighting potential relationships mediated by shared inflammatory or metabolic pathways.
1 citations
,
June 2022 in “International Journal of Dermatology” FFA in men shows unique features and treatment results vary widely.
2 citations
,
May 2022 in “Acta dermato-venereologica” In this study, patients with frontal fibrosing alopecia showed more actinic damage than control subjects, suggesting sunscreen use by these patients may be a consequence rather than a cause of the condition.
April 2022 in “JAAD International” This study suggests that vitamin D deficiency is likely not involved in the development of frontal fibrosing alopecia, as patients showed similar vitamin D levels to those with female pattern hair loss.
3 citations
,
February 2022 in “Journal of the American Academy of Dermatology” This article highlights a lack of published data on vitamin D deficiency prevalence among individuals with central centrifugal cicatricial alopecia, despite its known link to other forms of hair loss.
3 citations
,
February 2022 in “Dermatology practical & conceptual” This study found that trichoscopy is an effective noninvasive technique for diagnosing frontal fibrosing alopecia, confirming its valuable role alongside traditional histopathological examination.
3 citations
,
January 2022 in “Journal of The American Academy of Dermatology” This study found that sunscreen and moisturizer use was associated with a higher likelihood of developing frontal fibrosing alopecia in the reviewed studies.
4 citations
,
September 2021 in “Dermatopathology” This study suggests that erosive pustular dermatosis of the scalp may be part of the spectrum of autoinflammatory dermatoses, rather than a unique skin disorder.
5 citations
,
September 2021 in “Journal of The American Academy of Dermatology” This study found a high prevalence of beard and eyebrow alopecia in male patients with frontal fibrosing alopecia, and suggests a potential link between hormonal imbalances and the condition.
14 citations
,
September 2021 in “Journal of Inflammation Research” This study suggests that female patients with alopecia areata, especially those with nail abnormalities and atopic diseases, may have higher rates of coexisting autoimmune diseases.
7 citations
,
August 2021 in “Journal of the European Academy of Dermatology and Venereology” This study suggests that early initiation of treatment in fibrosing alopecia in a pattern distribution may lead to a more favorable outcome, as evident in some patients experiencing arrested disease progression and hair regrowth.
7 citations
,
July 2021 in “The Journal of Dermatology” This study in Asian females found that higher use of moisturizers and sunscreen among FFA patients may reflect appearance concerns rather than indicating a direct link to the disease mechanism.
12 citations
,
May 2021 in “Clinical Interventions in Aging” This study found that men with androgenetic alopecia have different scalp biophysical characteristics in androgen-sensitive areas compared to non-sensitive areas and healthy controls.
1 citations
,
April 2021 in “Journal of The American Academy of Dermatology” Some overweight or obese men with long-term frontal fibrosing alopecia may have abnormal sex hormone levels.
20 citations
,
March 2021 in “Drug design, development and therapy” This review summarizes the pharmacology, mechanisms, and clinical efficacy of topical immunotherapy for alopecia areata but reports no new clinical results.
January 2021 in “Türkiye klinikleri dermatoloji dergisi” This study found that eyebrow involvement in frontal fibrosing alopecia was more common among postmenopausal females with comorbidities, without a significant link to age or disease duration.
2 citations
,
October 2020 in “International Journal of Dermatology” This study found that lichen planopilaris in men typically presents similarly to women, with a lower likelihood of nonscalp hair loss and a higher association with mucosal lichen planus and thyroid disease.
9 citations
,
October 2020 in “Journal of the American Academy of Dermatology” Patients with central centrifugal cicatricial alopecia may have a higher risk of breast and colorectal cancer.
22 citations
,
August 2020 in “Journal of the American Academy of Dermatology” Women with lichen planopilaris and frontal fibrosing alopecia often have other health issues like hypothyroidism and lupus.
13 citations
,
August 2020 in “Mayo Clinic proceedings” In this study, women with lichen planopilaris were found to have high rates of thyroid disease, depression, and anxiety, and about half experienced slowed or stabilized disease progression with treatment.
9 citations
,
July 2020 in “Journal of Dermatology” This study found that diffuse and pseudo-fringe sign patterns are common in Asian patients with frontal fibrosing alopecia, and that treatments combining antiandrogens or antimalarials with topical therapy are effective.
8 citations
,
July 2020 in “Journal of The American Academy of Dermatology” Patients with Lichen Planopilaris are more likely to have rosacea and skin cancer but less likely to have congestive heart failure, stroke, and glaucoma.
10 citations
,
June 2020 in “Journal of Cosmetic Dermatology” This study found a high prevalence of genital Lichen sclerosus and autoimmune comorbidities in patients with frontal fibrosing alopecia, suggesting a possible shared autoimmune process.
34 citations
,
June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.
16 citations
,
April 2020 in “JAMA dermatology” More inflammation leads to faster and worse hair loss in women with frontal fibrosing alopecia.
24 citations
,
January 2020 in “JAAD Case Reports” This article discusses the staging of central centrifugal cicatricial alopecia in women of African descent and reports no new clinical results.
6 citations
,
October 2019 in “Case Reports in Dermatology” This report describes a case of fibrosing alopecia in a pattern distribution in a postmenopausal woman, highlighting its distinction from other forms of lichen planopilaris and pattern hair loss.
8 citations
,
October 2019 in “International Journal of Dermatology” This study examined 56 Thai patients with frontal fibrosing alopecia, finding frontotemporal hairline recession and eyebrow loss were common, and reported better disease stabilization with combination treatments of topical corticosteroids with hydroxychloroquine or finasteride.
7 citations
,
August 2019 in “Anais Brasileiros de Dermatologia” This study describes the demographic, clinical, and histopathological characteristics of 16 patients with frontal fibrosing alopecia and emphasizes the need for further research on its pathogenesis and treatment.
53 citations
,
June 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study observed that abnormal hormone levels were associated with lower disease activity in frontal fibrosing alopecia, while thyroid disorders were a common comorbidity among the affected population.
May 2019 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This study reviewed 38 cases of frontal fibrosing alopecia, observing that diagnosis often occurs years after onset and is more prevalent in postmenopausal women.
37 citations
,
January 2019 in “BioMed Research International” This review highlights that scalp pruritus is a complex condition with various underlying causes, making it a challenge to diagnose and manage effectively. It emphasizes the need for comprehensive patient evaluation, history-taking, and personalized treatment strategies to address quality of life impacts.
4 citations
,
January 2019 in “Acta dermato-venereologica” This study found that women with frontal fibrosing alopecia have a significantly higher prevalence of rosacea compared to controls, particularly those with severe alopecia, and certain factors like perifollicular erythema, higher BMI, and lower progesterone levels were linked to increased rosacea risk.
48 citations
,
November 2018 in “Journal of dermatological treatment” In a study reviewing 291 patients with lichen planopilaris, findings revealed that women were more commonly affected than men, cyclosporine and methotrexate were most effective in achieving remission, and 5-alpha reductase inhibitors and systemic retinoids were particularly beneficial for frontal fibrosing alopecia.
9 citations
,
October 2018 in “Journal of international medical research” This study found no correlation between the extent of frontal fibrosing alopecia and quality of life, but observed a strong association with thyroid disease in affected women.
25 citations
,
October 2018 in “Journal of The American Academy of Dermatology” This study concluded that erosive pustular dermatosis of the scalp may be a type of spongiotic, pustular superficial folliculitis, sharing similarities with other neutrophilic dermatoses.
21 citations
,
September 2018 in “International journal of women’s dermatology” In this study, patients with lichen planopilaris showed higher prevalence of autoimmune disorders like Hashimoto's thyroiditis and hypothyroidism compared to those with seborrheic dermatitis.
24 citations
,
June 2018 in “Reviews in endocrine and metabolic disorders” This review discusses the epidemiology, clinical manifestations, and pathogenesis of autoimmune skin diseases and their associations with thyroid diseases, reporting no new clinical results.
41 citations
,
June 2018 in “Journal of The American Academy of Dermatology” This study examined the therapeutic response to folliculitis decalvans treatments among 60 patients and found that earlier disease onset was linked to more severe cases, while a combination of rifampicin, clindamycin, tetracyclines, and intralesional steroids was most effective in controlling symptoms.
13 citations
,
April 2018 in “Journal of The American Academy of Dermatology” This study found that 64.8% of patients with different types of alopecia had vitamin D deficiency, and those with lichen planopilaris and telogen effluvium had higher odds of severe deficiency compared to patients with alopecia areata.
19 citations
,
April 2018 in “International Journal of Dermatology” This study found that female patients with frontal fibrosing alopecia are significantly more likely to have systemic lupus erythematosus compared to controls.
18 citations
,
February 2018 in “Journal of the American Academy of Dermatology” This study reports no new clinical results but suggests a potential relationship between frontal fibrosing alopecia and cutaneous conditions such as rosacea, indicating a need for further research.
13 citations
,
January 2018 in “International Journal of Trichology” In this study, intralesional triamcinolone acetonide injections were associated with halting the progression of frontal fibrosing alopecia in female patients and showed minimal adverse effects, but the efficacy as sole therapy remains unclear pending further trials.
25 citations
,
December 2017 in “Facial Plastic Surgery” This study observed that combining high-potency steroids with pimecrolimus might effectively stabilize hairline recession in frontal fibrosing alopecia patients.
36 citations
,
December 2017 in “Journal of the American Academy of Dermatology” This study observed that 70.7% of patients with frontal fibrosing alopecia stabilized with treatment, and patients using 0.3% tacrolimus were more likely to stabilize in 3 months compared to other treatments.
27 citations
,
June 2017 in “International Journal of Dermatology” This study found that acne keloidalis nuchae was associated with pseudofolliculitis barbae, chronic scalp folliculitis, and aspects of the metabolic syndrome, particularly hypertension, in the examined population.
53 citations
,
February 2017 in “Journal of The American Academy of Dermatology” In this study of 20 patients with erosive pustular dermatosis of the scalp, using trichoscopy improved diagnosis, and treatments with high-potency steroids or topical tacrolimus effectively reduced inflammatory signs, suggesting these as first-line treatments.
38 citations
,
January 2017 in “PPAR Research” This review discusses the role of PPAR-γ in the pathogenesis of primary cicatricial alopecia, including its involvement in lichen planopilaris and treatment trials using PPAR-agonists, and reports no new clinical results.
22 citations
,
January 2017 in “Acta Endocrinologica” A woman with multiple autoimmune diseases showed improvement in hair loss but not in skin discoloration after treatment.
29 citations
,
January 2016 in “International Journal of Dermatology” This study reports that the duration of hair loss is positively associated with the severity of central centrifugal cicatricial alopecia in African-American women.
3 citations
,
January 2016 in “US endocrinology” This study found no significant association between alopecia types and thyroid dysfunction, despite higher thyroid dysfunction rates in alopecia patients compared to the general U.S. population.
1 citations
,
December 2015 in “TURKDERM” This study found that treatment improved symptoms and stopped disease progression for 75% of lichen planopilaris patients whose follow-up data were available.
68 citations
,
February 2015 in “Journal of the European Academy of Dermatology and Venereology” This study found that severe folliculitis decalvans was associated with its onset before age 25 and the presence of pustules, while tetracyclines and clindamycin plus rifampicin were effective treatments.
43 citations
,
January 2015 in “Journal of Cutaneous Medicine and Surgery” This study found that most patients with folliculitis decalvans showed improvement and remission with oral antibiotics, although some experienced relapses and required prolonged treatment.
102 citations
,
April 2014 in “International Journal of Dermatology” This study found that early intervention and treatment with intralesional triamcinolone acetonide may stabilize hairline recession in patients with frontal fibrosing alopecia, although further research is needed for definitive treatment guidelines.
88 citations
,
April 2011 in “Archives of Dermatology” This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.
150 citations
,
October 2010 in “The American Journal of Pathology” This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.
25 citations
,
September 2010 in “Journal of Cutaneous Medicine and Surgery” This study found that central centrifugal cicatricial alopecia primarily affects adult women of African descent and suggests an association with traumatic hair care practices and delayed diagnosis.
155 citations
,
September 2008 in “British journal of dermatology/British journal of dermatology, Supplement” This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.
