Comorbid Conditions in Lichen Planopilaris: A Retrospective Data Analysis of 334 Patients

    September 2018 in “ International journal of women’s dermatology ”
    Nikoleta Brankov, Rosalynn R.Z. Conic, Natasha Atanaskova-Mesinkovska, Melissa Piliang, Wilma F. Bergfeld
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    TLDR People with Lichen planopilaris are more likely to have certain autoimmune and endocrine disorders but less likely to have conditions like allergies and diabetes.
    In a retrospective data analysis of 334 patients with Lichen planopilaris (LPP) compared to 78 control patients with seborrheic dermatitis, the study found that LPP was more prevalent in females (93.1% vs. 79.5%) and was positively associated with autoimmune and endocrine disorders such as Hashimoto's thyroiditis (6.3% vs. 0%), hypothyroidism (24.3% vs. 12.8%), and hirsutism (11.4% vs. 1.3%). Conversely, LPP was negatively associated with conditions like allergic rhinitis, type II diabetes mellitus, hyperlipidemia, vitamin D deficiency, depression, and sleep problems. The study, conducted at the Cleveland Clinic Foundation between 2000 and 2016, suggests that dermatologists should screen LPP patients for associated autoimmune disorders and conduct a full metabolic workup to identify any additional abnormalities. The findings highlight the need for a better understanding of the relationship between atopy, autoimmune and endocrine disorders, nutritional deficiencies, psychological problems, and skin cancers in patients with scarring alopecia.
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      Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

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      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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      in Research/Science  43 upvotes 6 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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      in Research/Science  96 upvotes 3 weeks ago
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      in Research  830 upvotes 7 months ago
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