Autoimmune Comorbid Diseases Associated with Lichen Planus: A Nationwide Case-Control Study

    December 2014 in “ Journal of the European Academy of Dermatology and Venereology ”
    Ping‐Hong Chung, Chian‐Yaw Hwang, Yi‐Ju Chen, M.‐W. Lin, T.‐J. Chen, Tuan‐Chun Hua, Liqing Wu, Shao‐Yin Chu, Celia Chen, D.‐D. Lee, Yan‐Tyng Chang, Han-Nan Liu
    TLDR Lichen planus is linked to several autoimmune diseases.
    The study investigated the association between lichen planus (LP) and various autoimmune diseases using data from the National Health Insurance Research Database of Taiwan, covering 12,427 patients with LP and 49,708 controls. Significant associations were found between LP and systemic lupus erythematosus (SLE) (mOR: 2.87), Sjögren's syndrome (mOR: 3.75), dermatomyositis (mOR: 6.34), vitiligo (mOR: 2.09), and alopecia areata (mOR: 2.82). Gender-stratified analyses showed that SLE and alopecia areata were significantly associated with LP in both genders, while the association with Sjögren's syndrome was significant only in females. The associations with dermatomyositis and vitiligo were not significant in either gender. The study concluded that LP is associated with various autoimmune diseases, suggesting the need for further research to understand the underlying mechanisms and the role of autoimmunity in LP's etiology.
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