Lichen Planus and Dyslipidemia: A Systematic Review and Meta-Analysis of Observational Studies

February 2016 in “ International Journal of Dermatology ”

Yi Chun Lai, Yik Weng Yew, Robert A. Schwartz

lichen planus dyslipidemia triglyceride LDL-C HDL-C total cholesterol cardiovascular risks LP low-density lipoprotein cholesterol high-density lipoprotein cholesterol

Studysummary This study found that patients with lichen planus were significantly more likely to have dyslipidemia, particularly with higher triglyceride levels.

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In 2016, a meta-analysis of seven studies with a total of 5242 subjects found that patients with lichen planus (LP) had a significantly higher likelihood of having dyslipidemia, with a pooled odds ratio of 1.74. Specifically, LP was associated with elevated triglyceride levels, but no significant association was found with LDL-C, HDL-C, or total cholesterol levels. Despite the study's limitations, such as heterogeneity among studies and potential publication bias, the findings suggest that LP patients may have an increased risk of dyslipidemia and could benefit from screening and management for this condition. The study calls for further research to confirm these findings and to explore the long-term cardiovascular risks associated with dyslipidemia in LP patients.

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Research cited in this study

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research Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

291 citations , January 2014 in “The Scientific World Journal”

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

research A Comparative Study of Dyslipidemia in Men and Women with Androgenic Alopecia

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This study found that both men and women with androgenic alopecia had significantly higher triglycerides, total cholesterol, and LDL-C and lower HDL-C levels than controls, suggesting increased dyslipidemia prevalence.