Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case-Control Study

    July 2015 in “ American Journal of Clinical Dermatology ”
    Leyla Baykal, Deniz Aksu Arıca, Savaş Yaylı, Asım Örem, Sevgi Bahadır, Ece Altun, Hüseyin Yaman
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    TLDR People with Lichen Planus, especially with mucosal involvement, are more likely to have Metabolic Syndrome, which increases their risk for heart disease and diabetes.
    In the 2015 case-control study with 79 patients with Lichen Planus (LP) and 79 matched controls, researchers discovered a significantly higher prevalence of Metabolic Syndrome (MS) in LP patients, at 26.6%, compared to 12.7% in controls. The prevalence was even higher, at 34.5%, in LP patients with mucosal involvement versus 8.3% in those without. LP patients also had higher mean fasting blood glucose and diastolic blood pressure. However, there were no significant differences in dyslipidemia and insulin resistance prevalence between LP patients and controls. The study suggests that LP patients, especially those with mucosal involvement, are at an increased risk for cardiovascular diseases and diabetes mellitus, and that clinicians should monitor cardiovascular risk factors in these patients. The study's limitations include its small sample size, and further research with larger populations is recommended.
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