Lipid Levels in Patients with Lichen Planus: A Case-Control Study

    February 2011 in “ Journal of the European Academy of Dermatology and Venereology ”
    Salvador Arias‐Santiago, A. Buendía‐Eisman, José Aneiros‐Fernández, María Sierra Girón-Prieto, María Teresa Gutiérrez-Salmerón, Valentin García‐Mellado, Antonio Cutando, Ramón Naranjo‐Sintes
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    TLDR People with lichen planus have higher bad cholesterol and lower good cholesterol, increasing their risk for heart disease.
    In a case-control study from Granada, Spain, with 160 participants (80 with lichen planus (LP) and 80 controls), researchers found that LP patients had significantly higher levels of triglycerides, total cholesterol, and LDL-C, and lower levels of HDL-C compared to controls. The study, which adjusted for age, weight, height, BMI, tobacco use, sedentarism, hypothyroidism, and drug intake, showed an adjusted odds ratio for dyslipidemia in LP patients of 3.03, indicating a threefold increase in risk. While the study suggests an association between LP and dyslipidemia, it acknowledges the need for more prospective studies to confirm these findings and to understand the mechanisms behind the increased cardiovascular risk in LP patients. The conclusion recommends considering lipid level screening in LP patients to potentially prevent cardiovascular disease.
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