The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

In 2016, a case-control study involving 140 participants (70 with cutaneous Lichen Planus (LP) and 70 healthy controls) found a significant association between cutaneous LP and Metabolic Syndrome (MS). The study found that 58.6% of LP patients had MS compared to 17.1% of controls, and 81.42% of LP patients had dyslipidemia compared to 31.7% of controls. Additionally, LP patients had significantly higher mean values of waist circumference, Body Mass Index (BMI), fasting blood sugar (FBS), triglycerides (TG), and both systolic and diastolic blood pressure. The study concluded that patients with cutaneous LP had a higher prevalence of MS, dyslipidemia, diabetes mellitus, and hypertension, suggesting the need for cardiovascular risk factor investigation and lifestyle modification in these patients. No significant association was found between gender, the concomitant involvement of oral mucosa, hair, or nail and MS.