An Overview of Growth Factors as the Potential Link Between Psoriasis and Metabolic Syndrome
December 2023
in “
Journal of Clinical Medicine
”
psoriasis metabolic syndrome growth factors b-FGF HGF NGF-β SCF PDGF-BB M-CSF VEGF EGF IGF-1 inflammation tissue remodeling metabolic regulation biomarkers obesity biological treatments basic fibroblast growth factor hepatocyte growth factor nerve growth factor beta stem cell factor platelet-derived growth factor BB macrophage colony-stimulating factor vascular endothelial growth factor epidermal growth factor insulin-like growth factor 1
TLDR Abnormal growth factor metabolism may link psoriasis and metabolic syndrome, and obesity can affect psoriasis treatment effectiveness.
This systematic review investigates the potential link between psoriasis and metabolic syndrome through the dysregulation of growth factors. It highlights the roles of growth factors such as b-FGF, HGF, NGF-β, SCF, PDGF-BB, M-CSF, VEGF, EGF, and IGF-1 in cellular processes central to both conditions. These growth factors are implicated in inflammation, tissue remodeling, and metabolic regulation, with potential as therapeutic targets or biomarkers. The review suggests that abnormal metabolism of these growth factors could connect psoriasis and metabolic syndrome, warranting further investigation. Additionally, it notes that obesity can reduce the efficacy of biological treatments for psoriasis, indicating a need for weight-adjusted dosing strategies.
