Pretreatment of Epidermal Growth Factor Promotes Primary Hair Recovery via the Dystrophic Anagen Pathway After Chemotherapy-Induced Alopecia

May 2013 in “ Experimental Dermatology ”

Seung Hwan Paik, Ji‐Seon Yoon, Hyeong Ho Ryu, Ji Yeon Lee, Chang Yup Shin, Kyung Hyun Min, Seong Jin Jo, Kyu Han Kim, Ohsang Kwon

epidermal growth factor chemotherapy-induced alopecia dystrophic anagen pathway catagen-like stage C57BL/6 mouse model EGF-liposomal solution catagen inducers EGF CIA

TLDR Epidermal growth factor helps hair recover after chemotherapy.

The study investigated the effects of epidermal growth factor (EGF) on chemotherapy-induced alopecia (CIA) using a C57BL/6 mouse model. Researchers applied a topical EGF-liposomal solution to hair follicles and found that EGF induced a catagen-like stage, which protected the hair from chemotherapy damage. This pretreatment promoted primary hair recovery through the dystrophic anagen pathway after CIA. The findings suggested that catagen inducers like EGF could serve as a novel strategy for protecting against alopecia, particularly in cases of CIA.

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Research cited in this study

9 / 9 results

research Chemotherapy-Induced Alopecia

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Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations , April 1994 in “PubMed”

Cyclosporine A slows down hair loss from chemotherapy in mice, while dexamethasone increases hair loss but speeds up regrowth.

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Pretreatment of Epidermal Growth Factor Promotes Primary Hair Recovery via the Dystrophic Anagen Pathway After Chemotherapy-Induced Alopecia

Research cited in this study

research Chemotherapy-Induced Alopecia

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

research Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies

research Protection Against Chemotherapy-Induced Alopecia

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

research The Biology of Hair Follicles

research Principles of Hair Cycle Control

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

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