M-CSF-Stimulated Myeloid Cells Can Convert Into Epithelial Cells to Participate in Re-Epithelialization and Hair Follicle Regeneration During Dermal Wound Healing

    June 2022 in “ PLOS ONE ”
    Yunyuan Li, Hatem Alnojeidi, Ruhangiz T. Kilani, Aziz Ghahary
    TLDR M-CSF-stimulated myeloid cells can turn into skin cells and help heal wounds and regrow hair.
    This study demonstrates that M-CSF-stimulated myeloid cells can convert into epithelial cells, contributing to re-epithelialization and hair follicle regeneration during dermal wound healing in a murine model. Using double immunofluorescent staining and cell tracing techniques, the researchers found that CD11b-positive myeloid cells could transform into keratinocytes, marked by keratin 14 expression, in the healing skin. Additionally, these converted cells were shown to aid in hair follicle regeneration. The findings highlight the significant role of myeloid cells in skin repair and hair growth, suggesting potential therapeutic applications for enhancing wound healing and treating hair loss.
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