Growth Factors and Cutaneous Pathology

    August 2020 in “ CRC Press eBooks
    Lloyd E. King, Lillian B. Nanney, Ronald E. Gates
    TLDR Abnormal growth factors can cause hair and skin issues.
    The document reviewed the role of growth factors and cytokines in regulating hair growth and their impact on hair follicle formation, structure, and the hair cycle. It highlighted how abnormalities in these factors could lead to abnormal hair or fur. Specifically, growth factors like epidermal growth factor and transforming growth factor (TFGα) were shown to influence regeneration rates after burn wounds. Additionally, transgenic mice overexpressing TGFβ-1 exhibited shiny, taut skin that restricted movement and breathing, demonstrating the significant effects of growth factor regulation on skin and hair pathology.
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