Unlocking the Potential of the Secretome in Hair Growth Enhancement

    August 2024 in “ International Journal of Basic & Clinical Pharmacology ”
    Nancy Suwarna, Veronika Maria Sidharta, Lorettha Wijaya, Sukmawati Tansil Tan
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    TLDR Secretome-based therapies could improve hair growth better than current treatments.
    This review explores the potential of the secretome in enhancing hair growth by examining the biological pathways of hair follicle development and regeneration. It highlights the role of hair follicle stem cells in wound healing and the influence of inflammatory cells. Exosomes from hair follicle mesenchymal stem cells containing lncRNA H19 were found to enhance diabetic wound healing. Hair follicle transplantation activates stem cells, with key molecular signaling pathways being crucial for regeneration. PlncRNA-1 promotes stem cell differentiation via the EZH2/ZEB1/MAPK1 axis. Secretome-based therapies show promise in stimulating hair follicles and promoting hair regeneration, potentially offering advantages over current treatments like minoxidil and finasteride.
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