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Glossary secretome

collection of molecules secreted by cells into their environment

The secretome refers to the collection of molecules, such as proteins and peptides, that are secreted by cells into their surrounding environment. These molecules play crucial roles in communication between cells, tissue repair, and immune responses. For example, in the context of hair biology, the secretome of hair follicle cells can influence hair growth and regeneration.

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research Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning

320 citations , December 2018 in “Frontiers in Immunology”

This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.

research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

271 citations , May 2019 in “Cells”

This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.

research Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery

26 citations , December 2016 in “Pharmacology & Therapeutics”

This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.

research Secretome of Mesenchymal Stromal Cells as a Possible Innovative Therapeutic Tool in Facial Nerve Injury Treatment

2 citations , January 2023 in “BioMed Research International”

This review discusses the potential of mesenchymal stromal cell secretome therapies for facial nerve palsy, emphasizing their standardization advantages over cell transplantation, but provides no new clinical results.

research The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

1 citations , March 2023 in “Pharmaceutics”

This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.

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community New Hair Loss Treatment: Adipose Derived Secretomes

18 upvotes 1 year ago

Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.

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