research Modeling the Onset of Senescence-Associated Secretory Phenotype Predicts Therapeutic Targets
The research found that blocking a gene called NEMO can potentially prevent harmful effects of aging at the cellular level.
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research Cellular Senescence in Tissue Repair: Every Cloud Has a Silver Lining
Cell aging can be both good and bad for tissue repair.
research Oncogenic Senescence: A Multi-Functional Perspective
Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.
research Cellular Senescence: Ageing and Androgenetic Alopecia
The review "Cellular Senescence: Ageing and Androgenetic Alopecia" explores the connection between ageing and androgenetic alopecia (AGA), the most common type of hair loss characterized by the miniaturization of hair follicles. It highlights that beyond genetic and androgen factors, ageing and the associated increase in senescent cells play a significant role in AGA. The review discusses how androgen and oxidative stress-induced senescence mechanisms contribute to AGA and suggests potential therapeutic strategies. These strategies include inhibiting the senescence of dermal papilla cells (DPCs) and hair follicle stem cells (HFSCs), removing senescent cells, and reducing the senescence-associated secretory phenotype (SASP).
research Inducing Fate Changes at the Hair Follicle Stem Cell Niche
The study found that aging hair follicle stem cells change behavior, leading to hair loss, but drugs targeting these cells may help restore hair growth.
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5 / 14 resultscommunity Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year
A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
community Countering oral minoxidil side effects by taking collagen supplements?
Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.
community Why is human evolution like this 😂
Why androgenic alopecia affects the scalp rather than other body parts, potential explanations for this phenomenon, treatments available to combat hair loss, and the implications of male attractiveness in modern society.
community I came across this 98 year old man and couldn’t help but notice the amazing hair this guy has. His hairline is better than mine and I’m 80 years younger.
User discusses a 98-year-old man with amazing hair and a better hairline than someone 80 years younger. Conversation includes various treatments like Minoxidil, Finasteride, and genetics as factors for hair quality.
community redensyl - follicle stem cell activator any experiences?
A Swiss product called Redensyl, which is supposed to target hair follicle stem cells and has recently been marketed in Europe. The post inquires if anyone has had any experience with the product.