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GlossarySenescence-Associated Secretory Phenotype

condition where aging cells release inflammatory molecules and enzymes

Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 735 upvotes 1 year ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 3 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Why is human evolution like this 😂

in Chat 2 years ago

Why androgenic alopecia affects the scalp rather than other body parts, potential explanations for this phenomenon, treatments available to combat hair loss, and the implications of male attractiveness in modern society.

community I came across this 98 year old man and couldn’t help but notice the amazing hair this guy has. His hairline is better than mine and I’m 80 years younger.

in Chat 704 upvotes 1 year ago

User discusses a 98-year-old man with amazing hair and a better hairline than someone 80 years younger. Conversation includes various treatments like Minoxidil, Finasteride, and genetics as factors for hair quality.

community redensyl - follicle stem cell activator any experiences?

in Question 7 upvotes 7 years ago

A Swiss product called Redensyl, which is supposed to target hair follicle stem cells and has recently been marketed in Europe. The post inquires if anyone has had any experience with the product.

community Update on hair, will be posting monthly! Nov 8 – Jan 14

in Progress Pictures 334 upvotes 1 year ago

A user's progress with treating their hair loss, including using finasteride, minoxidil, retinoic acid, dermapenning twice weekly and ket 2% shampoo two to three times per week. Other users offered advice such as not derma penning too often or shaving the area bald for a couple of months.

community Pyrilutamide update: three months

in Update 33 upvotes 1 year ago

A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

community 23M (yes 23, I'm not kidding), ~6 month progress. I'm on the Big 4 + Vitamin Supplement.

in Progress Pictures 449 upvotes 7 months ago

A 23-year-old male shared his 6-month hair loss progress using Minoxidil, Finasteride, Ketoconazole shampoo, microneedling, and vitamin supplements. He noticed hair loss at 19, which accelerated during the pandemic.

community Boys how is no one seeing positive results from pyrilutamide

in Chat 24 upvotes 1 year ago

Pyrilutimide, a treatment for hair loss; it's effectiveness compared to other treatments such as Finasteride and RU58841; and some users’ experiences with the treatment.

community Could low blood flow to the head cause an increased rate of thinning?

in Chat 29 upvotes 2 years ago

The user started using finasteride, minoxidil, and biotin for male pattern baldness (MPB) and is experiencing rapid thinning. They are questioning if low blood flow to the head could be contributing to their hair loss.

community The theory that explains everything. Please help me make this big!

in Research/Science 2446 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community 18 months. Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral, T/GEL

in Progress Pictures 169 upvotes 3 years ago

A 28 year old man's 18-month journey to treat his hair loss with Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral and T/GEL. He experienced some side effects along the way, including translucent semen and scalp less oily.

community People here just don't know what they are letting themselves in for!

in Chat 125 upvotes 6 months ago

The conversation discusses hair loss treatments, emphasizing the importance of patience and sticking with a treatment for at least 12-18 months before judging its effectiveness or adding new treatments. Users share experiences and agree that introducing treatments too quickly can lead to panic and negative outcomes.

community Who here has maintained with finasteride for decades?

in Finasteride/Dutasteride 133 upvotes 9 months ago

People have been using finasteride for 10 to 20+ years to maintain their hairline, with many reporting success and no significant side effects. Some users have combined finasteride with minoxidil for better results, and a few have switched to dutasteride or added hair transplants when finasteride was less effective.