Platelet Immune Interactions, Lifespan, and Senescence

Platelets, beyond their role in hemostasis, are crucial in immune interactions, as evidenced by increased platelet counts in patients with immune-related conditions following immunomodulatory treatments. These treatments have spurred the development of therapeutic monoclonal antibodies and other agents targeting immune system complexities. Platelets are significant in severe adenovirus infections and vaccinations, with activated platelets exhibiting shorter lifespans and early senescence in various diseases. Laboratory findings on senescence-associated secretory phenotypes may pave the way for new treatments, such as senolytics, targeting platelet particles. The document also discusses factors affecting platelet lifespan.