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Glossary Senescence-Associated Secretory Phenotype

condition where aging cells release inflammatory molecules and enzymes

Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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research 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets

April 2018 in “Journal of Investigative Dermatology”

This study found that inhibiting NF-κB Essential Modulator (NEMO) in senescent murine dermal fibroblasts successfully reduced key factors associated with the senescence associated secretory phenotype (SASP), highlighting its potential as a therapeutic target for aging-related diseases.

research Cellular senescence in tissue repair: every cloud has a silver lining

33 citations , January 2018 in “The International Journal of Developmental Biology”

This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.

research Oncogenic senescence: a multi-functional perspective

32 citations , February 2017 in “Oncotarget”

This workshop review discusses the dual role of cellular senescence in cancer, highlighting both its anticancer effects and pro-tumorigenic potential, while reporting no new research results.

research Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging

7 citations , March 2025 in “Free Radical Biology and Medicine”

This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.

research Platelet Immune Interactions, Lifespan, and Senescence

1 citations , January 2025 in “OBM Geriatrics”

This study highlights the role of platelets in immune interactions and severe adenovirus infection, noting that activated platelets have a shorter lifespan. Results suggest potential for developing therapies targeting platelet senescence and immunologic mechanisms.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Hair Loss TreatmentsDermatology
Associated Dermatologists | BerkleyBerkley, MI · US

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