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Glossary Senescence-Associated Secretory Phenotype

condition where aging cells release inflammatory molecules and enzymes

Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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research 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets

April 2018 in “Journal of Investigative Dermatology”

This study found that inhibiting NF-κB Essential Modulator (NEMO) in senescent murine dermal fibroblasts successfully reduced key factors associated with the senescence associated secretory phenotype (SASP), highlighting its potential as a therapeutic target for aging-related diseases.

research Cellular senescence in tissue repair: every cloud has a silver lining

33 citations , January 2018 in “The International Journal of Developmental Biology”

This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.

research Oncogenic senescence: a multi-functional perspective

32 citations , February 2017 in “Oncotarget”

This workshop review discusses the dual role of cellular senescence in cancer, highlighting both its anticancer effects and pro-tumorigenic potential, while reporting no new research results.

research Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging

7 citations , March 2025 in “Free Radical Biology and Medicine”

This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.

research Platelet Immune Interactions, Lifespan, and Senescence

1 citations , January 2025 in “OBM Geriatrics”

This study highlights the role of platelets in immune interactions and severe adenovirus infection, noting that activated platelets have a shorter lifespan. Results suggest potential for developing therapies targeting platelet senescence and immunologic mechanisms.

research Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

December 2025 in “Pharmaceutics”

In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.

research 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs

July 2024 in “Journal of Investigative Dermatology”

Bioengineered skin models aging well, useful for studying aging and testing treatments.

research LB1672 Senescent melanocytes in nevus skin stimulate hair growth

August 2023 in “Journal of Investigative Dermatology”

Senescent melanocytes in nevus skin boost hair growth.

research Cellular Senescence: Ageing and Androgenetic Alopecia

January 2023 in “Dermatology”

This review summarizes biological links between aging and androgenetic alopecia, particularly focusing on cellular senescence, and discusses potential therapeutic strategies, but reports no new clinical results.

Inducing Fate Changes at the Hair Follicle Stem Cell Niche

research 1349 Inducing fate changes at the hair follicle stem cell nice

April 2023 in “Journal of Investigative Dermatology”

In this study, using a mouse model, researchers found that inducing senescence in hair follicle stem cells led to hair regeneration failure and sebaceous gland enlargement, akin to androgenetic alopecia features.

Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

This study reported that an ex vivo organ culture system effectively induced aging-related changes in healthy human skin, allowing testing of senolytics like tretinoin, resveratrol, and caffeine.

research The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease

November 2025 in “Biocell”

This article explores how the integrated stress response and senescence-associated secretory phenotype influence stem cell fate decisions, highlighting their dual roles in both protecting and disrupting stem cell integrity.

research Il-10 family members as novel responders to genotoxic stress

January 2015 in “ScholarlyCommons (University of Pennsylvania)”

This study discovered that DNA damage independently induces IL-19 and IL-24 cytokines, which regulate senescence-associated secretory phenotype factors, suggesting potential pathways for treating cancer and age-related diseases.

research Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective

2 citations , December 2025 in “Annals of Medicine”

This review discusses the complex correlation between cellular senescence and PCOS, emphasizing senescence markers, mechanisms, and potential anti-senescence therapies, but reports no new clinical results.

research Update on Melasma—Part I: Pathogenesis

10 citations , July 2022 in “Dermatology and Therapy”

This review discusses the pathogenesis of melasma, including genetic, environmental, and hormonal factors, and highlights potential avenues for new treatments and preventive strategies, but reports no new experimental findings.

research Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects

February 2026 in “Frontiers in Immunology”

In this review, researchers detail how immunosenescence and chronic neuroinflammation contribute to Parkinson's disease progression, exploring potential therapeutic strategies targeting this axis, such as senolytic agents and immune rejuvenation, while highlighting associated challenges and future research needs.

research Metformin and Malignant Tumors: Not Over the Hill

14 citations , August 2021 in “Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy”

This research discusses the potential antitumor effects of metformin, a common diabetes medication, noting its controversial influence on different malignant tumors and its uncertain mechanisms. Understanding these effects on tumors may aid in the development of new cancer treatments.

research Dermal papilla cells and melanocytes response to physiological oxygen levels depends on their interactions

7 citations , June 2021 in “Cell Proliferation”

This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.

research Aged Skin Cells Nurture Stem Cells toward Regeneration

3 citations , October 2023 in “Journal of Investigative Dermatology”

Aged skin cells can help hair growth by stimulating stem cells.

research 090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells

July 2024 in “Journal of Investigative Dermatology”

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

research OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

6 citations , November 2022 in “Antioxidants”

In this study, sandalore was found to activate OR2AT4, which inhibits senescent cell traits and restores proliferation in human keratinocytes, suggesting potential anti-aging applications.

research Keratinocyte Stem Cells: Role in Aging

1 citations , March 2022 in “IntechOpen eBooks”

This article reviews the functions and locations of skin stem cells and their role in regeneration and differentiation, relating age-associated skin changes to decreased stem cell functionality; it reports no new experimental findings.

research Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy

December 2023 in “Redox biology”

In this study, DMC selectively eliminated senescent cells in old mice, prevented hair loss, improved motor coordination, and reduced senescence-associated secretory factors, suggesting its potential as a senolytic treatment.

research The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

68 citations , September 2018 in “Trends in Cell Biology”

This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.

research Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

56 citations , March 2015 in “Cell death and differentiation”

This study found that H-Ras activation in aged mouse skin leads to increased dysplasia and progression to in situ squamous cell carcinoma, highlighting an age-linked connection between immune changes, senescence, and cancer risk.

research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis

September 2025 in “Arthritis Research & Therapy”

In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.

research Evaluation of the phenotypic, proliferative and secretory profile of mesenchymal stem cells from adipose tissue captured by laser-assisted liposuction

April 2023 in “Digital Library of Theses and Dissertations (Universidade de São Paulo)”

This study concluded that mesenchymal stem cells from adipose tissue harvested using laser-assisted liposuction with selective photo-stimulation are as effective and low-risk for cell therapy as those obtained through conventional liposuction, based on their differentiation potential, cellular proliferation, and cytokine expression.

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

research Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

3 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

This study found that the purified compound VB1 from Vitex negundo seeds may reduce UVA-induced skin aging by targeting MAPK1 and demonstrated its potential in mice.

research Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage

20 citations , February 2017 in “International Journal of Dermatology”

This study found that the small molecule honokiol may protect against inflammation, collagen breakdown, and cell damage caused by cigarette smoke in skin cells cultured in vitro.

research Minoxidil Regulates Aging-Like Phenotypes in Rat Cortical Astrocytes In Vitro

1 citations , December 2022 in “Biomolecules & therapeutics”

This study found that a long-term astrocyte culture model can effectively study astrocyte senescence and suggests minoxidil as a potential candidate to regulate brain aging by normalizing dysregulated gene expression in aged astrocytes.