The Opportunities and Challenges Regarding Induced Platelets from Human Pluripotent Stem Cells

May 2021 in “ Stem Cells International ”

Mengxue Xu, Liping Liu, Yumei Li, Yun‐Wen Zheng

human pluripotent stem cells induced platelets iPlatelets gene-editing CRISPR/Cas9 tumorigenicity hPSCs CRISPR

TLDR Human pluripotent stem cells could be used to make platelets for medical use, but safety, effectiveness, and cost issues need to be resolved.

The document discusses the potential of human pluripotent stem cells (hPSCs) to produce induced platelets (iPlatelets) for therapeutic purposes, which could address the clinical demand for platelets and overcome challenges such as short shelf life and allogeneic immunity. Various methods have been studied to optimize the production of functional iPlatelets, including gene-editing techniques like CRISPR/Cas9. iPlatelets have shown similar kinetics to fresh normal platelets and can adhere to injured sites, leading to clot formation. However, there are challenges to overcome for large-scale production and clinical application of iPlatelets, including potential tumorigenicity, low yield, low functionality, and high cost. The document concludes that safety assessment, full functionality evaluation, and cost control are still essential for the large-scale production and clinical application of iPlatelets.

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