Organoids in Skin Wound Healing

    January 2025 in “ Burns & Trauma
    Zitong Wang, Feng Zhao, Hongxin Lang, Haiyue Ren, Qiqi Zhang, Xing Huang, Cai He, Chengcheng Xu, Cher‐Han Tan, Jiajie Ma, S Duan, Zhe Wang
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    TLDR Skin organoids help improve wound healing and tissue repair.
    The article explores the potential of skin organoids, derived from stem cells, in enhancing wound healing by replicating skin architecture and promoting tissue regeneration. These organoids can form structures like hair follicles and sweat glands, aiding in wound reconstruction. Recent advancements, including iPSCs and 3D printing, have shown promise in integrating organoids with host tissues, enhancing healing in animal models. Despite challenges such as consistency and ethical concerns, organoids offer promising applications in regenerative medicine and drug development. Future research aims to optimize their clinical use, potentially improving outcomes for patients with severe skin injuries.
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