Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device

    March 2024 in “ Advanced healthcare materials/Advanced Healthcare Materials ”
    Cristina Quílez, Eun Young Jeon, Alberto Pappalardo … Hasan Erbil Abaci
    Studysummary This study found that generating pluripotent stem cell-derived skin organoids in a 3D bioprinted hydrogel device improved keratinocyte differentiation and hair follicle formation while reducing necrosis.
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    Research cited in this study 9

    1. Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids Stem cell reports · 2022
    2. Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells Nature Protocols · 2022
    3. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    4. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    5. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    6. Next Generation Human Skin Constructs as Advanced Tools for Drug Development Experimental Biology and Medicine · 2017
    7. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    8. Anatomy and Physiology of the Skin Journal of the Dermatology Nurses’ Association · 2011
    9. Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis Genes & Development · 2008