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This study found that generating pluripotent stem cell-derived skin organoids in a 3D bioprinted hydrogel device improved keratinocyte differentiation and hair follicle formation while reducing necrosis.

In this study, researchers developed a microfluidics-based method to generate hair follicle germs on a large scale for potential hair regeneration therapies, demonstrating efficient hair follicle regeneration following transplantation into mice.

Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.

Mesenchymal stiffness affects sweat gland cell development.

This study found that carefully engineered hydrogels and asymmetric morphogen gradients facilitated the formation of anatomically relevant skin organoids from iPSC-derived EBs, improving pigmentation and hair follicle generation.