A Human Prenatal Skin Cell Atlas Reveals Immune Cell Regulation of Skin Morphogenesis

October 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Nusayhah Hudaa Gopee, Ni Huang, Bayanne Olabi, Chloe Admane, Rachel Botting, April Rose Foster, Fereshteh Torabi, Elena Winheim, Dinithi Sumanaweera, Issac Goh, Mohi Miah, Emily Stephenson, Win Tun, Pejvak Moghimi, Ben Rumney, Peng He, Scott Lawrence, Kenny Roberts, Keval Sidhpura, Justin Englebert, Laura Jardine, Gary Reynolds, Antony Rose, Clarisse Gânier, Vanessa Rowe, Sophie Pritchard, Ilaria Mulas, James Fletcher, Dorin-Mirel Popescu, Elizabeth Poyner, Anna Dubois, Andrew Filby, Steven Lisgo, Roger A. Barker, Jong-Eun Park, Roser Vento‐Tormo, Phuong A. Le, Sara A. Serdy, Jin Kim, CiCi Deakin, Jiyoon Lee, Marina Nikolova, Neil Rajan, Stéphane Ballereau, Tong Li, Josh Moore, Dave Horsfall, Daniela Basurto Lozada, Edel A. O’Toole, Barbara Treutlein, Omer Ali Bayraktar, Maria Kasper, Pavel Mazin, Laure Gambardella, Karl R. Koehler, Sarah A. Teichmann, Muzlifah Haniffa

Studysummary This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

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