A Human Prenatal Skin Cell Atlas Reveals Immune Cell Regulation of Skin Morphogenesis

    October 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Nusayhah Hudaa Gopee, Ni Huang, Bayanne Olabi, Chloe Admane, Rachel Botting, April Rose Foster, Fereshteh Torabi, Elena Winheim, Dinithi Sumanaweera, Issac Goh, Mohi Miah, Emily Stephenson, Win Tun, Pejvak Moghimi, Ben Rumney, Peng He, Scott Lawrence, Kenny Roberts, Keval Sidhpura, Justin Englebert, Laura Jardine, Gary Reynolds, Antony Rose, Clarisse Gânier, Vanessa Rowe, Sophie Pritchard, Ilaria Mulas, James Fletcher, Dorin-Mirel Popescu, Elizabeth Poyner, Anna Dubois, Andrew Filby, Steven Lisgo, Roger A. Barker, Jong-Eun Park, Roser Vento‐Tormo, Phuong A. Le, Sara A. Serdy, Jin Kim, CiCi Deakin, Jiyoon Lee, Marina Nikolova, Neil Rajan, Stéphane Ballereau, Tong Li, Josh Moore, Dave Horsfall, Daniela Basurto Lozada, Edel A. O’Toole, Barbara Treutlein, Omer Ali Bayraktar, Maria Kasper, Pavel Mazin, Laure Gambardella, Karl R. Koehler, Sarah A. Teichmann, Muzlifah Haniffa
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    TLDR Immune cells are essential for early hair and skin development and healing.
    The study presents the first comprehensive multi-omic reference atlas of prenatal human skin, focusing on the period between 7-16 weeks post-conception. It combines single-cell and spatial transcriptomic data to characterize the cellular organization of the skin's microenvironment. The findings show that interactions between immune and non-immune cells are crucial for hair follicle formation, scarless wound healing, and skin angiogenesis. The study also evaluates a skin organoid model derived from human embryonic stem (ES) and induced pluripotent stem (iPS) cells, finding that while it closely mimics epidermal and dermal components during hair follicle development, it lacks immune cells and shows reduced endothelial cell diversity and quantity. Importantly, macrophages and macrophage-derived growth factors are identified as key drivers of endothelial development in prenatal skin. The addition of autologous iPS-derived macrophages to endothelial cell angiogenesis assays and skin organoid cultures enhanced vascular network formation. This research highlights the dual role of innate immune cells in skin morphogenesis and their interaction with non-immune cells, and it uses the prenatal skin cell atlas to advance understanding of genetic hair and skin disorders.
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