Therapeutic Potential of Endogenous Stem Cells and Cellular Factors for Scar-Free Skin Regeneration

The document reviews the potential of using endogenous stem cells and cellular factors for scar-free skin regeneration, drawing insights from animal models that naturally regenerate skin without scarring. It emphasizes the importance of understanding the role of endogenous stem cells, the TGF-β pathway, and other molecular factors in human skin regeneration. The review suggests that activating local skin stem cells could be a new strategy for scar-free healing, which could have significant clinical and cosmetic benefits. It also discusses the limitations of current scar treatments, the psychological impact of scars, and the therapeutic potential of stem cell-based treatments to prevent skin fibrosis and scarring. The document further explores the role of various signaling pathways and molecules in collagen expression and scarring, the importance of skin stem cells in the hair follicle bulge, and the potential of targeting TGF-β signaling for preventing skin scarring. However, it notes that no effective therapies based on this pathway are currently available and calls for further research into regenerative models and local skin stem cells to develop new pharmacological strategies for scar-free skin regeneration. The document is a review and does not report specific study participant numbers.