Therapeutic Potential of Endogenous Stem Cells and Cellular Factors for Scar-Free Skin Regeneration

    November 2018 in “ Drug Discovery Today ”
    Shibashish Giri, Hans‐Günther Machens, Augustinus Bader
    Image of study
    TLDR Using skin stem cells and certain molecules might lead to scar-free skin healing.
    The document reviews the potential of using endogenous stem cells and cellular factors for scar-free skin regeneration, drawing insights from animal models that naturally regenerate skin without scarring. It emphasizes the importance of understanding the role of endogenous stem cells, the TGF-β pathway, and other molecular factors in human skin regeneration. The review suggests that activating local skin stem cells could be a new strategy for scar-free healing, which could have significant clinical and cosmetic benefits. It also discusses the limitations of current scar treatments, the psychological impact of scars, and the therapeutic potential of stem cell-based treatments to prevent skin fibrosis and scarring. The document further explores the role of various signaling pathways and molecules in collagen expression and scarring, the importance of skin stem cells in the hair follicle bulge, and the potential of targeting TGF-β signaling for preventing skin scarring. However, it notes that no effective therapies based on this pathway are currently available and calls for further research into regenerative models and local skin stem cells to develop new pharmacological strategies for scar-free skin regeneration. The document is a review and does not report specific study participant numbers.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 94 results

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Dutasteride Vs. Testosterone, who wins?

      in Finasteride/Dutasteride  58 upvotes 7 months ago
      The conversation discusses whether 2.5mg of dutasteride or 200mg of testosterone weekly is more influential in preventing hair loss, with various personal experiences indicating that the effectiveness is dependent on the individual's genetic profile. Some users report that dutasteride is likely to be more effective at the given doses.

      community Chris Bumstead Hair Tansplant at Now Hair Time

      in Transplants  476 upvotes 11 months ago
      Chris Bumstead got a hair transplant at Now Hair Time, and the discussion focuses on why he chose a less reputable clinic despite having the means for a better one, with some suggesting it was for financial gain. The conversation also touches on concerns about the naturalness of the hairline and the potential impact of his steroid use on the transplant's success.

    Related Research

    3 / 3 results