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research Tissue-engineered dermal substitutes constructed by human embryonic stem cell-derived fibroblasts facilitate the repair of skin wounds

March 2026 in “Frontiers in Bioengineering and Biotechnology”

In this study, researchers demonstrated that fibroblasts derived from human embryonic stem cells can be used to create tissue-engineered dermal substitutes, effectively repairing mouse skin wounds within 20 days, highlighting a promising method for clinical applications in skin repair.

research Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures

3 citations , August 2018 in “Stem cells international”

This study found that cultured hair follicle dermal cells support maintenance and potentially aid in the clinical application of pluripotent and haematopoietic stem cells.

research Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells

4 citations , September 2024 in “Development”

This study investigated transcription factors in human trophectoderm cells during development, finding that GATA2 and GATA3 are essential for transforming stem cells into induced trophoblast stem cells, which display characteristics similar to placental progenitor cells, offering new methods for modeling placental-associated diseases.

research Targeted delivery of siRNA to human cancer and human embryonic stem cells with cell level resolution

January 2016 in “Munich Personal RePEc Archive (Ludwig Maximilian University of Munich)”

This study demonstrated that a light-activated RNAi approach using hollow gold nanoshells effectively targets human prostate cancer cells with reduced off-target toxicity and material use compared to standard methods.

research Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells

7 citations , March 2017 in “Experimental and Therapeutic Medicine”

This study found that human hair follicle-derived mesenchymal stem cells effectively maintained human embryonic stem cells in an undifferentiated state, comparable to mouse embryonic fibroblasts under standard conditions.

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community Hair and normal skin created from human pluripotent stem cells for the first time

86 upvotes 6 years ago

Human pluripotent stem cells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.

community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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