The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

April 2009 in “ Differentiation ”

Abdelhak Belmadani, Hosung Jung, Dongjun Ren, Richard J. Miller

SDF-1 CXCL12 CXCR4 melanocyte progenitors hair follicles outer root sheath dermal papilla melanoblast chemokine signaling hair pigmentation follicle regeneration stromal cell-derived factor 1 melanocyte stem cells hair roots hair bulb pigment cells hair color hair growth

TLDR SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

The study demonstrated that the chemokine SDF-1/CXCL12 and its receptor CXCR4 played a crucial role in the migration and positioning of melanocyte progenitors in mouse hair follicles. SDF-1/CXCL12 acted as a guidance cue for CXCR4-expressing progenitor cells, directing their migration within the outer root sheath towards the dermal papilla. Disruption of CXCR4 signaling resulted in abnormal melanoblast concentration, indicating a migration defect. The findings highlighted the importance of chemokine signaling in hair pigmentation and follicle regeneration, providing insights into the molecular mechanisms underlying hair growth and pigmentation.

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