The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

April 2009 in “ Differentiation ”

Abdelhak Belmadani, Hosung Jung, Dongjun Ren, Richard J. Miller

SDF-1 CXCL12 CXCR4 melanocyte progenitors hair follicles outer root sheath dermal papilla melanoblast chemokine signaling hair pigmentation follicle regeneration stromal cell-derived factor 1 melanocyte stem cells hair roots hair bulb pigment cells hair color hair growth

TLDR SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

The study demonstrated that the chemokine SDF-1/CXCL12 and its receptor CXCR4 played a crucial role in the migration and positioning of melanocyte progenitors in mouse hair follicles. SDF-1/CXCL12 acted as a guidance cue for CXCR4-expressing progenitor cells, directing their migration within the outer root sheath towards the dermal papilla. Disruption of CXCR4 signaling resulted in abnormal melanoblast concentration, indicating a migration defect. The findings highlighted the importance of chemokine signaling in hair pigmentation and follicle regeneration, providing insights into the molecular mechanisms underlying hair growth and pigmentation.

View this study on europepmc.org →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations, October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations, August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?

130 citations, December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle melanocytes die during hair regression.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations, January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

research Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth

109 citations, July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

Similar Research

5 / 200 results

research CXCL12 Inhibits Hair Growth Through CXCR4

April 2022 in “Biomedicine & Pharmacotherapy”

CXCL12 protein slows down hair growth through its receptor CXCR4. Blocking this can potentially increase hair growth.

research A Human Prenatal Skin Cell Atlas Reveals Immune Cell Regulation of Skin Morphogenesis

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Immune cells are essential for early hair and skin development and healing.

iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

research iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

19 citations, December 2016 in “PLOS ONE”

Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.

research Biology of Melanocytes in Mammals

3 citations, November 2023 in “Frontiers in cell and developmental biology”

Melanocytes are important for skin and hair color and protect the skin from UV damage.

research Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration

May 2023 in “Journal of Investigative Dermatology”

Blocking DPP4 can potentially speed up hair growth and regeneration, especially after injury or in cases of hair loss.