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GlossaryCXCL12 (SDF-1)

signaling protein involved in immune response and tissue repair

CXCL12, also known as Stromal cell-derived factor 1 (SDF-1), is a protein that plays a crucial role in the body's immune response and tissue repair. It acts as a signaling molecule, attracting cells to areas where they are needed, such as sites of injury or inflammation. This protein is also important in the development and maintenance of various tissues, including hair follicles, and has been studied for its potential role in conditions like alopecia.

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research The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

57 citations, April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations, December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

research LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

53 citations, April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

research Effect of Porcine Acellular Dermal Matrix on the Expression of Stromal Cell-Derived Factor-1 and Wnt3a/β-Catenin Signaling Pathway in Mice Hair Follicle Regeneration

February 2019 in “Chin J Injury Repair and Wound Healing(Electronic Edition)”

Porcine acellular dermal matrix helps hair growth by boosting specific proteins and signals.

Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

research Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

49 citations, March 2014 in “Journal of Investigative Dermatology”

Using the drugs AMD3100 and Tacrolimus together greatly improves skin healing and hair growth after a deep skin cut by increasing stem cells in the wound.

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community Verteporfin with Microneedling (3mm-3.5mm): Bald to Full Head of Hair? Theory

in Technology 208 upvotes 11 months ago

The conversation is about using Verteporfin with microneedling as a potential hair loss treatment that may regenerate hair follicles with minimal scarring. There are concerns about the optimal dosage and the DHT sensitivity of the new follicles.