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GlossaryCXCL12 (SDF-1)

signaling protein involved in immune response and tissue repair

CXCL12, also known as Stromal cell-derived factor 1 (SDF-1), is a protein that plays a crucial role in the body's immune response and tissue repair. It acts as a signaling molecule, attracting cells to areas where they are needed, such as sites of injury or inflammation. This protein is also important in the development and maintenance of various tissues, including hair follicles, and has been studied for its potential role in conditions like alopecia.

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Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

research Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

49 citations , March 2014 in “Journal of Investigative Dermatology”

Using the drugs AMD3100 and Tacrolimus together greatly improves skin healing and hair growth after a deep skin cut by increasing stem cells in the wound.

research LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

53 citations , April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

research The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

57 citations , April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

research Mendelian Randomization Identifies CD25+ CD4+ Tregs and Plasma Proteins in Androgenetic Alopecia Pathogenesis

November 2025 in “DOAJ (DOAJ: Directory of Open Access Journals)”

CD25+ CD4+ Tregs and certain plasma proteins are linked to hair loss.

research Injectable Silk Nanofiber Hydrogels as Stem Cell Carriers to Accelerate Wound Healing

15 citations , January 2021 in “Journal of Materials Chemistry B”

Silk nanofiber hydrogels help stem cells heal wounds faster and improve skin regeneration.

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community Verteporfin with Microneedling (3mm-3.5mm): Bald to Full Head of Hair? Theory

in Technology 208 upvotes 2 years ago

The conversation is about using Verteporfin with microneedling as a potential hair loss treatment that may regenerate hair follicles with minimal scarring. There are concerns about the optimal dosage and the DHT sensitivity of the new follicles.