iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

    December 2016 in “ PLOS ONE ”
    Huan Zhang, Ningxia Zhu, Keng Yen Huang, Bozhi Cai, Yang Zeng, Yanming Xu, Yang Liu, Yanping Yuan, Lin Changmin
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    TLDR Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.
    In 2016, researchers studied the role of early-passage dermal papilla cells (DPCs) in hair follicle regeneration. They found that the culture medium from early passage DPCs induced hair follicle regeneration in mice, while the one from late passage DPCs did not. Using iTRAQ-based quantitative proteomic technology, they identified 1360 proteins, 213 of which were differentially expressed between the early and late-passage DPCs. These proteins regulated the Wnt, TGF-ß and BMP signaling pathways, which are involved in hair follicle morphogenesis and regeneration. The study concluded that DPC-secreted proteins, specifically SDF1, MMP3, biglycan, and LTBP1, play important roles in hair follicle regeneration.
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