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GlossaryCXCL12 (SDF1)

signaling protein involved in immune response and tissue repair

CXCL12, also known as Stromal cell-derived factor 1 (SDF-1), is a protein that plays a crucial role in the body's immune response and tissue repair. It acts as a signaling molecule, attracting cells to areas where they are needed, such as sites of injury or inflammation. This protein is also important in the development and maintenance of various tissues, including hair follicles, and has been studied for its potential role in conditions like alopecia.

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research Role of Sdf1-Cxcr4 Signaling in Mouse Appendage Regeneration

April 2016 in “Journal of Investigative Dermatology”

Mice without the p21 gene can fully regenerate injured ears due to reduced Sdf1 increase and leukocyte recruitment, suggesting new ways to induce tissue regeneration in mammals.

iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

research iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

19 citations, December 2016 in “PLOS ONE”

Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.

research Post-Finasteride Syndrome: Real or Imagined?

2 citations, April 2016 in “The Journal of Urology”

Finasteride 1mg linked to diverse symptoms; other treatments improve erectile function in rats.

research CXCL12 Inhibits Hair Growth Through CXCR4

April 2022 in “Biomedicine & Pharmacotherapy”

CXCL12 protein slows down hair growth through its receptor CXCR4. Blocking this can potentially increase hair growth.

research Stem Cells in the Body

November 2017

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

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community Verteporfin with Microneedling (3mm-3.5mm): Bald to Full Head of Hair? Theory

in Technology 209 upvotes 1 year ago

The conversation is about using Verteporfin with microneedling as a potential hair loss treatment that may regenerate hair follicles with minimal scarring. There are concerns about the optimal dosage and the DHT sensitivity of the new follicles.