Induction of Hair Follicle Regeneration in Rat Ear by Microencapsulated Human Hair Dermal Papilla Cells

    February 2009 in “ Chinese Journal of Traumatology (english Edition) ”
    Lin Changmin, Yu You Li, Ying-Chan Ji, Keng Yen Huang, Xiang-na Cai, Guoqiang Li
    Image of study
    TLDR Human hair cells can be used to grow new hair on rat ears, suggesting a possible treatment for hair loss.
    In 2009, a study was conducted on 20 rats to test the potential of microencapsulated human hair dermal papilla (DP) cells in inducing hair follicle regeneration. The DP cells were obtained from human scalp follicles and encapsulated using a high-voltage electric field droplet generator. These encapsulated cells were then transplanted into the rats' ears. After 4-12 weeks, 18 out of 20 rats showed high-density hair growth. The regenerated follicles were larger than normal rat ear follicles, and white, thick, regular-sized hair fiber was visible six weeks post-transplantation. The study concluded that the microencapsulated DP cells retained the capacity to initiate follicle regeneration, suggesting potential use in hair loss treatment and studying the pathomechanism of androgenetic alopecia.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community How Does Exosome Therapy Work for Hair Loss?

      in Research/Science  5 upvotes 1 year ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

      community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

      in Research/Science  13 upvotes 7 months ago
      A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Similar Research

    5 / 1000+ results