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GlossaryMelanoblasts

precursor cells that develop into melanin-producing melanocytes

Melanoblasts are precursor cells that develop into melanocytes, the cells responsible for producing melanin, the pigment that gives color to our skin, hair, and eyes. These cells originate from the neural crest during embryonic development and migrate to various parts of the body where they differentiate into melanocytes.

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research Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles

70 citations, May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Notch/RBP-J signaling is crucial for proper placement and timing of melanocyte development in hair follicles.

research Survival of Patchwork Melanoblasts Is Dependent Upon Their Number in the Hair Follicle at the End of Embryogenesis

29 citations, June 1998 in “Developmental Biology”

More melanoblasts in hair follicles mean better survival and proper hair pigmentation.

research Any Route for Melanoblasts to Colonize the Skin

19 citations, April 2016 in “Experimental Dermatology”

Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.

research Preservation of Melanoblasts in White Hair Follicles of Segmental Vitiligo Lesions: A Preliminary Study

7 citations, May 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

White hair follicles in vitiligo have fewer and less functional melanocytes.

research Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture

April 2019 in “Journal of Investigative Dermatology”

The created skin model with melanoblasts improves the study of skin color and offers an alternative to animal testing.

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