Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells

    March 2022 in “ Nature Protocols ”
    Jiyoon Lee, Wouter H. van der Valk, Sara A. Serdy … Karl R. Koehler
    Studysummary This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.
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    Research cited in this study 11

    1. Skin Organoids: A New Human Model for Developmental and Translational Research Experimental Dermatology · 2021
    2. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    3. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    4. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    5. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017
    6. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    7. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    8. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    9. To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders Seminars in Cell & Developmental Biology · 2013
    10. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    11. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005