Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells
March 2022
in “
Nature Protocols
”
hair-bearing skin organoids human pluripotent stem cells 3D in vitro culture system surface ectoderm cranial neural crest cells epidermis dermis hair follicles stratified skin layers pigmented hair follicles sebaceous glands Merkel cells sensory neurons fetal skin skin biology skin disease skin tissue regeneration stem cells 3D culture skin layers oil glands touch cells nerve cells skin regeneration
TLDR Scientists created hair-growing skin models from stem cells, which could help treat hair loss and skin diseases.
Researchers developed a protocol to generate hair-bearing skin organoids from human pluripotent stem cells in a 3D culture system. Over 2 weeks, the stem cells differentiated into surface ectoderm and cranial neural crest cells, forming the epidermis and dermis. By 60 days, the organoids produced hair follicles, and by 130 days, they achieved full complexity, mimicking fetal skin tissue at 18 weeks of gestation. These organoids, which can be maintained for up to 150 days, provide a valuable model for studying skin biology, disease, and potential skin tissue regeneration. This advancement could lead to new treatments for hair loss and skin diseases.
