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research 329 In vitro co-culture models of merkel cell-neurite complex in touch domes

October 2021 in “Journal of Investigative Dermatology”

In this research, investigators used in vitro models to study the Merkel cell-neurite complex and reported that mechanical stimulation, similar to gentle touch, can induce molecular changes that are potentially relevant to hair growth, thus contributing to the understanding of its underlying mechanisms.

research Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells

39 citations , March 2022 in “Nature Protocols”

This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.

research Touch Receptors Undergo Rapid Remodeling in Healthy Skin

31 citations , November 2016 in “Cell Reports”

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

research Three-Dimensional Morphology of Touch Domes in Human Hairy Skin by Correlative Light and Scanning Electron Microscopy

19 citations , February 2013 in “Journal of Investigative Dermatology”

Touch domes in human skin are complex sensory structures not directly linked to hair.

research Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages

5 citations , January 2024 in “Science Advances”

In this study, researchers identified Tenascin-C as a marker for touch dome keratinocytes, which maintain themselves and can develop into Merkel cells following injury, showing they share molecular traits with various epidermal keratinocytes.

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community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Hypoxia (lack of oxygen) enhances hair growth via stem cells

49 upvotes 1 year ago

Hypoxia may enhance hair growth by stimulating stem cells, but it could also risk fibrosis. Some users humorously discuss extreme methods like choking while using minoxidil, highlighting the need for new treatments.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community New study: Vitamin D counteracts DHT in mice and in human hair organ culture and hair cells

126 upvotes 1 year ago

Vitamin D may counteract DHT and help with hair growth, as seen in mice and human hair cultures. Some users discuss using Vitamin D, magnesium, and other supplements for hair health, while others humorously note the success in mice.

community Drug-free hair transplant while waiting for future treatments to become available to public: stupid or good plan?

in Transplants 1 month ago

A user plans a drug-free hair transplant while waiting for future treatments like stem cell therapies, which are projected to be available between 2028 and 2030. Many users express skepticism about the availability of new treatments, suggesting that relying on them is risky and that finasteride remains the most effective option.

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