Polycomb-Mediated Repression and Sonic Hedgehog Signaling Regulate Merkel Cell Specification

    April 2016 in “ Journal of Investigative Dermatology ”
    Elena Ezhkova, Carolina N. Perdigoto, Katherine L. Dauber
    Studysummary This study found that Sonic hedgehog signaling is crucial for Merkel cell development around hair follicles in mice, with Polycomb repressive complex 2 loss causing ectopic Merkel cells across all hair types.
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