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Overactivated Sonic Hedgehog Signaling Aggravates Intrauterine Adhesion by Inhibiting Autophagy in Endometrial Stromal Cells

research Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

52 citations , September 2020 in “Cell Death and Disease”

This study found that impaired autophagy plays a role in sonic hedgehog pathway-induced endometrial fibrosis, suggesting it as a potential target for treating intrauterine adhesion.

research Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage

30 citations , September 2014 in “Journal of Investigative Dermatology”

This study found that certain chemotherapeutic agents, such as cyclophosphamide, disrupt feather formation and induce hair loss in mice by inhibiting cell proliferation through sonic hedgehog gene downregulation.

research Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation

23 citations , October 2021 in “FEBS Journal”

This review examines the role of Sonic Hedgehog signaling in the maintenance and repair of skin and lung barriers, and its influence on inflammation and atopic diseases; it presents no new clinical findings.

research Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling

5 citations , January 2025 in “Burns & Trauma”

This study suggests that activating the PPARs/SHH-mitochondrial axis may enhance diabetic wound healing by improving endothelial cell metabolism and angiogenesis, indicating potential for PPAR agonists in treating diabetic foot ulcers.

research Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling

5 citations , October 2023 in “Aging”

This study found that activating SHH signaling in EPCs enhances angiogenesis to aid in healing pressure ulcers through the PI3K/AKT/eNOS pathway, indicating SHH signaling as a potential target for treatment.

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community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community Most Promising Future Hair Loss Treatments In 2026

83 upvotes 1 week ago

Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

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