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GlossaryHedgehog signaling pathway

regulates cell growth and development through protein-receptor interactions

The Hedgehog signaling pathway is a crucial mechanism in developmental biology that regulates cell growth, differentiation, and tissue patterning. It involves the Hedgehog proteins binding to receptors on cell surfaces, which then trigger a cascade of intracellular events that influence gene expression. This pathway is essential for proper embryonic development and, when dysregulated, can lead to conditions such as cancer and congenital disorders.

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research Polycomb-Mediated Repression and Sonic Hedgehog Signaling Regulate Merkel Cell Specification

April 2016 in “Journal of Investigative Dermatology”

Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.

Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations, June 2018 in “Frontiers in pharmacology”

Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.

research Author Response: Lhx2 as a Progenitor-Intrinsic Modulator of Sonic Hedgehog Signaling During Early Retinal Neurogenesis

October 2022

Lhx2 is a crucial regulator of the Sonic Hedgehog signaling in early mouse retinal development.

research MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling

118 citations, August 2010 in “Developmental Cell”

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

research A Non-Cell Autonomous Dermal Hedgehog Signaling Mechanism for Follicular Neoplasia and Induction

April 2023 in “Journal of Investigative Dermatology”

Mutations in the SHH pathway in certain skin cells can cause skin tumors and abnormal hair growth.

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community Maybe oral min was not that good of an idea for someone this naturally hairy

in Satire 413 upvotes 1 year ago

User discusses increased body hair after using oral minoxidil for hair loss treatment. Others share experiences and debate benefits of being hairy versus bald.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 2 months ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community Stemson Therapeutics Announces Technological Breakthrough in new Hair Growth

in Research/Science 61 upvotes 10 months ago

Stemson Therapeutics announced a breakthrough in hair growth technology using stem cells. Users discussed the potential high cost and skepticism about the treatment's accessibility.

community New company working on grey hair reversal

in Research/Science 98 upvotes 1 year ago

A conversation about hair loss and the desire for treatments to reverse balding and grey hair. The conversation mentions the use of minoxidil (Minoxidil) for hair growth and the potential for it to darken grey hair. Finasteride (Fin) is also mentioned as a treatment that turned someone's blonde hair brunette.

community Take The Jump - Get The Hair Transplant

in Progress Pictures 338 upvotes 1 year ago

User got a hair transplant and it improved their life. Transplanted hair lasts, but medication like finasteride is needed to maintain non-transplanted hair.