A Non-Cell Autonomous Dermal Hedgehog Signaling Mechanism for Follicular Neoplasia and Induction

April 2023 in “ Journal of Investigative Dermatology ”

S. Li, A. Shah, E. Sanchez-Ortiz … E. Olson

SHH signaling pathway Gorlin syndrome epidermal tumors follicular tumors Twist2-CreERT2 R26-tdTO dermal sheath Smo expression follicular neoplasms hair morphogenesis Wnt-mediated mechanism scarring alopecia Sonic Hedgehog signaling pathway skin tumors hair tumors Twist2-CreERT2 model R26-tdTO model hair growth Wnt signaling scarring hair loss

Studysummary This study found that in a mouse model of Gorlin syndrome, constitutive activation of signaling in dermal cells led to abnormal follicular growth, indicating non-epidermal factors may contribute to the disease.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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