Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

    June 2018 in “ Frontiers in pharmacology ”
    Haihua Zhang, Weixiao Nan, Shiyong Wang, Xuguang Song, Huazhe Si, Tong Li, Guangyu Li
    Image of study
    TLDR Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.
    The study from June 26, 2018, demonstrated that Epigallocatechin-3-gallate (EGCG), a compound found in green tea, promotes the growth of mink hair follicles at concentrations of 0.5-2.5μM. This effect is likely due to the increased proliferation of dermal papilla cells (DPCs) and outer root sheath cells (ORSCs), which are critical for hair growth. The study showed that EGCG treatment led to more cells entering the S phase of the cell cycle, with an upregulation of cyclin D1 and cyclin E1. The growth-promoting effects were associated with the activation of the sonic hedgehog (Shh) and AKT signaling pathways in hair follicles, DPCs, and ORSCs. Inhibition of these pathways partially reversed EGCG's effects, suggesting their involvement in mediating EGCG's action on hair follicle growth.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    5 / 5 results

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community My stack and 9 months progress (Nov, 2024 to July, 2025)

      in Is this regrowth?  33 upvotes 7 months ago
      The user shared their hair regrowth progress using a regimen including omega-3, flaxseed, EGCG, green tea, zinc, copper, probiotics, microneedling, topical finasteride, and minoxidil. Other users expressed skepticism about the effectiveness of the regimen, suggesting more proven treatments or considering a hair transplant.

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 6 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

    Similar Research

    5 / 441 results