Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

August 2006 in “ Molecular and Cellular Biology ”

Maria Kasper, Harald Schnidar, Graham W. Neill, Michaela Hanneder, Stefan Klingler, Leander Blaas, Carmen Schmid, Cornelia Hauser‐Kronberger, Gerhard Regl, Michael P. Philpott, Fritz Aberger

Epidermal Growth Factor EGF Hedgehog/GLI pathway keratinocytes gene expression skin cell behavior

Studysummary This study found that EGFR signaling modulates GLI target gene expression, potentially influencing outer root sheath cell specification and hair growth, and may have implications for cancer.

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The study investigated how Epidermal Growth Factor (EGF) signaling influenced the expression of Hedgehog/GLI target genes in human keratinocytes. It was found that EGF signaling selectively modulated the expression of these target genes, which are crucial for various cellular processes. The research provided insights into the complex interactions between EGF and Hedgehog/GLI pathways, highlighting the potential for targeted therapeutic strategies in conditions involving aberrant signaling, such as cancer. The study contributed to a better understanding of the molecular mechanisms underlying skin cell behavior and disease.

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