Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

    August 2006 in “ Molecular and Cellular Biology ”
    Maria Kasper, Harald Schnidar, Graham W. Neill … Fritz Aberger
    Studysummary This study found that EGFR signaling modulates GLI target gene expression, potentially influencing outer root sheath cell specification and hair growth, and may have implications for cancer.
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    Research cited in this study 9

    1. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005
    2. GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter Journal of Investigative Dermatology · 2004
    3. FOXE1, A New Transcriptional Target Of GLI2, Is Expressed In Human Epidermis And Basal Cell Carcinoma Journal of Investigative Dermatology · 2004
    4. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    5. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    6. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997
    7. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    8. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    9. IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures PubMed · 1993