TLDR EGF signaling affects gene expression in skin cells, influencing hair growth and potentially cancer.
The study investigated how Epidermal Growth Factor (EGF) signaling influenced the expression of Hedgehog/GLI target genes in human keratinocytes. It was found that EGF signaling selectively modulated the expression of these target genes, which are crucial for various cellular processes. The research provided insights into the complex interactions between EGF and Hedgehog/GLI pathways, highlighting the potential for targeted therapeutic strategies in conditions involving aberrant signaling, such as cancer. The study contributed to a better understanding of the molecular mechanisms underlying skin cell behavior and disease.
113 citations
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September 2005 in “Journal of Investigative Dermatology” Applying a special compound can promote hair growth without harmful side effects.
171 citations
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June 2004 in “Journal of Investigative Dermatology” 92 citations
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May 2004 in “Journal of Investigative Dermatology” 333 citations
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March 2000 in “Proceedings of the National Academy of Sciences” Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.
380 citations
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March 2000 in “Proceedings of the National Academy of Sciences” Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.
638 citations
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October 1997 in “Nature” 107 citations
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June 1997 in “PubMed” EGFR is essential for normal hair development and follicle differentiation.
94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
30 citations
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August 1993 in “PubMed” IL-1 alpha stops hair follicle growth and hair production.
October 2025 in “Gene Expression” Exosome therapy could be a promising new way to treat hair loss.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
March 2009 in “Dermatology Online Journal” Manipulating EGFR signaling may help treat hair loss and promote hair growth.
39 citations
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March 2009 in “Dermatology Online Journal” Understanding EGFR roles could lead to new hair loss treatments.
52 citations
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September 2018 in “International Journal of Molecular Sciences” Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.
