GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter

    June 2004 in “ Journal of Investigative Dermatology ”
    Mohammed S. Ikram, Graham W. Neill, Gerhard Regl … Michael P. Philpott
    Studysummary GLI2 activates GLI1, promoting skin tumor growth and hair development.
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    Research cited in this study 3

    1. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    2. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    3. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997